DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and Egfr

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_113695.2	Gene:	Egfr / 24329	RGDID:	2543	Length:	1209	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	103/389 - (26%)
Similarity:	171/389 - (43%)	Gaps:	66/389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRL--------PTIS 294
            |....:.|.||||:|.:|:|:..|       |...|..    |:::..:.:||        |
  Rat   642 PKIPSIATGIVGGLLFIVVVALGI-------GLFMRRR----HIVRKRTLRRLLQERELVEP--- 692

  Fly   295 STAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYR 359
                    :.||...|..|.|               |.|:|...:|.:|     :..|.||.:|:
  Rat   693 --------LTPSGEAPNQAHL---------------RILKETEFKKIKV-----LGSGAFGTVYK 729

  Fly   360 GTYNDCQE-----VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFV 416
            |.:....|     |.:|.:.:..|......:|.|:.::....:|:|..:|||   |.....|..:
  Rat   730 GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLM 794

  Fly   417 LYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLR 481
            .|..      |..::::  :..::.:...:....|:|..|.:|.:..::|:|:||||.::.....
  Rat   795 PYGC------LLDYVRE--HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 851

  Fly   482 VKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546
            ||:||..|::.|...:.....:|...||||::||::....|...|||||:||.:||:.|.|..||
  Rat   852 VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 916

  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            ..|...|:...|:.|.||.||..|..:::.||..||......||.|.:|.:..|:......||:
  Rat   917 DGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYL 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	77/277 (28%)
		Pkinase_Tyr	343..599	CDD:285015	75/263 (29%)
Egfr	NP_113695.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900