DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and FLT4

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:726 Identity:154/726 - (21%)
Similarity:257/726 - (35%) Gaps:236/726 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 LNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKR-------KKIC 155
            ||:|.:.|....|    :.|.|.........:..::|.:...|.:...:|...|       ..:|
Human   670 LNLSTLHDAHGNP----LLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVC 730

  Fly   156 LREEQD------SAHEEY---------------------DDDDLDLLQTARKGHGGDIHYVDRND 193
              |.||      ..|::|                     ..|.|::.......|...|  |...|
Human   731 --EVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSI--VWYKD 791

  Fly   194 EHV--------VANGHQAPEKQRPVVTESPVGR-----GNSGGSKRDFDPMLRENLVPPASGLVT 245
            |.:        :|:.:|....||  |.|...||     .|:.|.......:..|......|..:.
Human   792 ERLLEEKSGVDLADSNQKLSIQR--VREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIV 854

  Fly   246 LIVG-GILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTIT 309
            ::|| |::| |....|:|:.:|    :.|.|::..  ||            |.:.||.:.|..: 
Human   855 ILVGTGVIA-VFFWVLLLLIFC----NMRRPAHAD--IK------------TGYLSIIMDPGEV- 899

  Fly   310 PTYATLTRPFRE------YEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGR--------IYRG 360
                    |..|      |:....||.|.         |:.|..::..|.||:        |::|
Human   900 --------PLEEQCEYLSYDASQWEFPRE---------RLHLGRVLGYGAFGKVVEASAFGIHKG 947

  Fly   361 TYNDCQEVLVKTVAQHASQLQVNLLLQE-SMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSV 424
              :.|..|.||.:.:.|:..:...|:.| .::::..:|.||:::||...:... |.::.......
Human   948 --SSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQG-PLMVIVEFCKY 1009

  Fly   425 RNLKSFLQ------DPSYARS-------------------------------------------- 439
            .||.:||:      .|...:|                                            
Human  1010 GNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASP 1074

  Fly   440 -----------VTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDL 493
                       :|....|....|:|..||.|.:...||:|:||||.::.:...||:.|..|:||:
Human  1075 DQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI 1139

  Fly   494 FPG-DYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEID-PYEMEH 556
            :.. ||...|.... |:||::.|::....|...|||||||||:||:.:||..||..:. ..|...
Human  1140 YKDPDYVRKGSARL-PLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQ 1203

  Fly   557 YLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL-----------------QICLSEFHT 604
            .|:||.|:..|......:..||..||:..|..||:||:|                 ::|::...:
Human  1204 RLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSS 1268

  Fly   605 Q------------ITRYVX--------PAVLKHAKTCKY----------------NKRRRRKIFQ 633
            |            :..::         |::.:|:...:|                ....|.|.|:
Human  1269 QSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFE 1333

  Fly   634 QTTSSTLFPKT 644
            :      ||.|
Human  1334 E------FPMT 1338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 12/65 (18%)
PTK_Ryk 336..606 CDD:270639 87/370 (24%)
FLT4XP_011532780.1 Ig_2 214..301 CDD:464026
IgI_VEGFR 307..406 CDD:409448
Ig strand A 307..311 CDD:409448
Ig strand A' 317..321 CDD:409448
Ig strand B 323..332 CDD:409448
Ig strand C 339..344 CDD:409448
Ig strand C' 347..349 CDD:409448
Ig strand D 353..361 CDD:409448
Ig strand E 366..374 CDD:409448
Ig strand F 384..390 CDD:409448
Ig strand G 395..401 CDD:409448
IgI_VEGFR-3 408..495 CDD:409449
Ig strand A 409..414 CDD:409449
Ig strand A' 419..424 CDD:409449
Ig strand B 426..437 CDD:409449
Ig strand C 441..447 CDD:409449
Ig strand C' 449..452 CDD:409449
Ig strand D 455..457 CDD:409449
Ig strand E 459..464 CDD:409449
Ig strand F 472..480 CDD:409449
Ig strand G 486..495 CDD:409449
Ig_3 636..732 CDD:464046 12/67 (18%)
Ig 755..842 CDD:472250 17/90 (19%)
Ig strand B 772..776 CDD:409353 1/3 (33%)
Ig strand C 785..789 CDD:409353 2/5 (40%)
Ig strand E 808..812 CDD:409353 1/3 (33%)
Ig strand F 822..827 CDD:409353 1/4 (25%)
VEGFR-2_TMD 847..881 CDD:375470 10/38 (26%)
PTKc_VEGFR3 914..1253 CDD:270680 88/351 (25%)
Blue background indicates that the domain is not in the aligned region.

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