Protein Alignment drl and FGFR3

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 169/633 - (26%)
• Similarity: 248/633 - (39%)
• Gaps: 142/633 - (22%)

  Fly    75 VDHPLPYSINIATSDTEVLPRPILN---------------IS------------RIGDVPVEPQT 112
            ||...||.......|.::|..|..|               ||            |||.:.:..|.
Human   146 VDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210

  Fly   113 WGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFK-----RKKICLREEQDSAHEEYDDDDL 172
            |.:.:                |.::.....|.|.::..     |:...|...:.|.|.......|
Human   211 WSLVM----------------ESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL 259

  Fly   173 DLLQTARKGHGGDIH---YVDRND-----EHVVANGHQAPEKQRPVVT----------ESPVGRG 219
            ...|||..|...:.|   |.|...     :||..||.:......|.||          |:.|...
Human   260 PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLR 324

  Fly   220 NSGGSKRDFDPML------------------------RENLVPP------ASGLVTLIVGGILAL 254
            .:..|:||....|                        .|.||..      .:|:::..||..| .
Human   325 LANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFL-F 388

  Fly   255 VLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPF 319
            :||...:.:......|.|...|..||.|.....:|..|:|..::.|:    |:.||    |.|..
Human   389 ILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNASM----SSNTP----LVRIA 445

  Fly   320 REYEHE-PEEFNRRLQEL------TVQKCRVRLSCLVQEGNFGRIYR----GTYNDCQ----EVL 369
            |....| |...|....||      .:.:.|:.|...:.||.||::..    |...|..    .|.
Human   446 RLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVA 510

  Fly   370 VKTVAQHASQLQVNLLLQE-SMMLYEASHPNVLSVLGISIED---YATPFVLYAATGSVRNLKSF 430
            ||.:...|:...::.|:.| .||.....|.|::::||...:.   |.  .|.|||.|   ||:.|
Human   511 VKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV--LVEYAAKG---NLREF 570

  Fly   431 LQ-------DPSY------ARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRV 482
            |:       |.|:      ...:|....|....|:|..||:|.:...||:|:||||.::.:...:
Human   571 LRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 635

  Fly   483 KLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYA 547
            |:.|..|:||:...||.........|:||::.|||....|...|||||||||:||:.|||..||.
Human   636 KIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP 700

  Fly   548 EIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595
            .|...|:...||:|:|:.:|.||..:|:.||..||.:.|::||:|.||
Human   701 GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	19/113 (17%)
		PTK_Ryk	336..606	CDD:270639	97/291 (33%)
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443	18/109 (17%)
		Ig strand A	151..154	CDD:409443	2/2 (100%)
		Ig strand A'	162..167	CDD:409443	1/4 (25%)
		Ig strand B	171..179	CDD:409443	0/7 (0%)
		Ig strand C	185..190	CDD:409443	2/4 (50%)
		Ig strand C'	193..195	CDD:409443	0/1 (0%)
		Ig strand D	204..207	CDD:409443	0/2 (0%)
		Ig strand E	211..216	CDD:409443	1/20 (5%)
		Ig strand F	225..232	CDD:409443	2/6 (33%)
		Ig strand G	235..245	CDD:409443	2/9 (22%)
		IgI_3_FGFR	253..354	CDD:409363	21/100 (21%)
		Ig strand A	253..256	CDD:409363	0/2 (0%)
		Ig strand A'	260..264	CDD:409363	0/3 (0%)
		Ig strand B	272..279	CDD:409363	1/6 (17%)
		Ig strand C	283..290	CDD:409363	0/6 (0%)
		Ig strand D	305..310	CDD:409363	2/4 (50%)
		Ig strand E	321..326	CDD:409363	1/4 (25%)
		Ig strand F	334..342	CDD:409363	1/7 (14%)
		Ig strand G	345..353	CDD:409363	0/7 (0%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	97/291 (33%)