Protein Alignment drl and ERBB4

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_016859066.1
• Gene: ERBB4 / 2066
• HGNCID: 3432
• Length: 1349
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 167/763 - (21%)
• Similarity: 276/763 - (36%)
• Gaps: 220/763 - (28%)

  Fly     9 GLLLTLIASGQAHLNIFLNLHE-----VLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVT 68
            |.|::......::::.|:|..:     :..:.|:..:.|...| ||:...||    |...:.::|
Human   366 GSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIE-AIDPEKLN----VFRTVREIT 425

  Fly    69 --FTWQSLVDHPLPYSI--NIATSDTEVL--PRPILNISRIGDVPVEPQTWGIALKCSGTRNAEV 127
              ...||...:...:|:  |:.|....||  ...:|.:.:.|...::.|    :||.....|..:
Human   426 GFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQ----SLKEISAGNIYI 486

  Fly   128 T-----------------VTINVEVIL--DRATNNNT------NLI------------------- 148
            |                 .|||..:::  :|...|.|      |.:
Human   487 TDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRR 551

  Fly   149 FKRKKICLR--EEQDSAHEEYDDDDL------------DLLQTARKGHGGD-----IHYVD-RND 193
            |.|.:||:.  ...|....|:::..:            |.|.|.. |.|.|     .|:.| .|.
Human   552 FSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCH-GPGPDNCTKCSHFKDGPNC 615

  Fly   194 EHVVANGHQA----------PEKQ----RPVVTESPVGRGNS---GGSKRDFDPMLRENLVPPAS 241
            .....:|.|.          |:::    .|..|:..:|....   |...|...|...:.:..|.:
Human   616 VEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRCNGPTSHDCIYYPWT 680

  Fly   242 GLVTL------------IVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTIS 294
            |..||            ::||:..||:|.....:....|...|:....  ..::|...:.|
Human   681 GHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALR--RFLETELVEPL---- 739

  Fly   295 STAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYR 359
                     .||...|..|.|               |.|:|..:::.:|     :..|.||.:|:
Human   740 ---------TPSGTAPNQAQL---------------RILKETELKRVKV-----LGSGAFGTVYK 775

  Fly   360 GTYNDCQEVLVKTVA----QHASQLQVNL-LLQESMMLYEASHPNVLSVLGISIEDYATPFVLYA 419
            |.:....|.:...||    ...:..:.|: .:.|::::....||:::.:||:.:.
Human   776 GIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS---------- 830

  Fly   420 ATGSVRNLKSFLQDPSYARSVTTIQTVL------------------MGSQL--------AMAMEH 458
                                 .|||.|.                  :||||        |..|.:
Human   831 ---------------------PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMY 874

  Fly   459 LHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGD---YNSLGDGEYRPIKWLSLEALQKS 520
            |....::|:|:||||.::.....||:||..|:| |..||   ||:  ||...||||::||.:...
Human   875 LEERRLVHRDLAARNVLVKSPNHVKITDFGLAR-LLEGDEKEYNA--DGGKMPIKWMALECIHYR 936

  Fly   521 HYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASM 585
            .:...|||||:||.:||:.|.|..||..|...|:...|:.|.||.||..|..:::.:|..||...
Human   937 KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 1001

  Fly   586 PAERPSFSQLQICLSEFHTQITRYVXPAVLKHAKTCKYNKRRRRKIFQ 633
            ...||.|.:|....|.......||:   |::.....|.......|.||
Human  1002 ADSRPKFKELAAEFSRMARDPQRYL---VIQGDDRMKLPSPNDSKFFQ 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	36/190 (19%)
		PTK_Ryk	336..606	CDD:270639	81/303 (27%)
ERBB4	XP_016859066.1	Recep_L_domain	55..167	CDD:460032
		Furin-like	215..358	CDD:395614
		Recep_L_domain	384..504	CDD:460032	24/128 (19%)
		GF_recep_IV	528..660	CDD:464344	22/132 (17%)
		TM_ErbB4	683..726	CDD:213053	9/42 (21%)
		PTKc_HER4	751..1053	CDD:173655	92/353 (26%)