DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drl and ERBB3

DIOPT Version :9

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_001973.2 Gene:ERBB3 / 2065 HGNCID:3431 Length:1342 Species:Homo sapiens


Alignment Length:505 Identity:125/505 - (24%)
Similarity:211/505 - (41%) Gaps:102/505 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 FKRKKICLR-------EEQDSAHE----EYDDDDLDLLQTAR-KGHGGD-----IHYVDRNDEHV 196
            :.|..:|:.       |.::.|||    ....:...:..||. .|.|.|     .|:  |:..|.
Human   523 YSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHF--RDGPHC 585

  Fly   197 VAN------GHQAPEKQRPVVTES--PVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGG--- 250
            |::      |.:.|..:.|.|...  |.....:.|.|   .|.|::.|     |...:::|.   
Human   586 VSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCK---GPELQDCL-----GQTLVLIGKTHL 642

  Fly   251 ILALVLVSTLILIAYCAKG----------PSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCP 305
            .:||.:::.|::|.....|          .:||....  :|.:..|.:  |...|...|.:    
Human   643 TMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRR--YLERGESIE--PLDPSEKANKV---- 699

  Fly   306 STITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQE--- 367
                     |.|.|:|.|         |::|.|          :..|.||.:::|.:....|   
Human   700 ---------LARIFKETE---------LRKLKV----------LGSGVFGTVHKGVWIPEGESIK 736

  Fly   368 --VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSF 430
              |.:|.:...:.:.....:....:.:....|.:::.:||:...........|...||:      
Human   737 IPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSL------ 795

  Fly   431 LQDPSYARSVTTIQTVL-MGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLF 494
            |......|.....|.:| .|.|:|..|.:|..||::|:::||||.::....:|::.|..:: ||.
Human   796 LDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA-DLL 859

  Fly   495 PGDYNSLGDGEYR-PIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYL 558
            |.|...|...|.: ||||::||::....|...|||||:||.:||:.|.|..|||.:...|:...|
Human   860 PPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLL 924

  Fly   559 KDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITR 608
            :.|.|||||..|..:::.:|..||......||:|.:|   .:|| |::.|
Human   925 EKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL---ANEF-TRMAR 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 2/7 (29%)
PTK_Ryk 336..606 CDD:270639 79/276 (29%)
Pkinase_Tyr 343..599 CDD:285015 74/262 (28%)
ERBB3NP_001973.2 Recep_L_domain 56..167 CDD:279382
FU 180..215 CDD:214589
Furin-like 183..329 CDD:279142
FU 226..266 CDD:238021
Recep_L_domain 353..474 CDD:279382
GF_recep_IV 499..630 CDD:291509 24/111 (22%)
FU 500..553 CDD:238021 6/29 (21%)
FU 548..592 CDD:214589 9/45 (20%)
TM_ErbB3 638..676 CDD:213056 7/37 (19%)
PTK_HER3 701..979 CDD:173656 85/300 (28%)
Pkinase_Tyr 709..965 CDD:285015 77/275 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..999
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1152
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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