DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and ERBB2

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_001369713.1 Gene:ERBB2 / 2064 HGNCID:3430 Length:1294 Species:Homo sapiens


Alignment Length:412 Identity:79/412 - (19%)
Similarity:132/412 - (32%) Gaps:143/412 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 PFDPLTETELKLVRNIINKSYPIGHNHKFTFQ-------------YVGLNEPEKSLVLSWHSSPD 79
            |..|..|.|:|      ...|..|:|..||..             :|......:....::|  ||
Human   737 PLPPRKEQEIK------ESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYH--PD 793

  Fly    80 ----------------RNVKPPPRQAFVIARD--KGMSR--EIVID----------FST-RAIVS 113
                            .||.|.|.|.||.:|.  :|.:|  .::.:          |.| |.:.|
Human   794 GTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPS 858

  Fly   114 NKIHVGNGN-PMLTIDEQQAATAVVQKYKPFCDSIIKRGLNLSEVVVTSSTMGWFGETKTKRFIR 177
                :.||| ..|....::.:.|...:...| ....||| ..|.....:|..||...::.....|
Human   859 ----ISNGNYSQLQFQAREYSGAPYSQRDNF-QQCYKRG-GTSGGPRANSRAGWSDSSQVSSPER 917

  Fly   178 TIPFYLNGSV----NTYLRPIE------GMTII-VNL----DQMKVTGFKDRFTGPMPKANGREY 227
            ....:.:|..    :..:.|::      ..||: |::    .||:|.     |:..         
Human   918 DNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVA-----FSAA--------- 968

  Fly   228 RISKLKPPFGPSLRSAVVFQPDGPGFKIDGHVVRWANWEFHMSFDVRAGLVISLASIFDMDMNRY 292
            |.|.|.|        ..:.||                    :.||:   |:.:|...||:.:.|:
Human   969 RTSNLAP--------GTLDQP--------------------IVFDL---LLNNLGETFDLQLGRF 1002

  Fly   293 RQVLYKGHLSEMFVPYMDPNDDWYFISYLDCGEFGCGQTAVSLEPYTDCPPNAAFMDGIFPGQDG 357
            .               ...|..:.||       |...:.||::..|.:...|...:...: ..||
Human  1003 N---------------CPVNGTYVFI-------FHMLKLAVNVPLYVNLMKNEEVLVSAY-ANDG 1044

  Fly   358 TPT-KISNVMCIFEKYAGDIMW 378
            .|. :.::...|.:.:.||.:|
Human  1045 APDHETASNHAILQLFQGDQIW 1066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 38/173 (22%)
PTK_Ryk 336..606 CDD:270639 9/44 (20%)
ERBB2NP_001369713.1 Recep_L_domain 52..173 CDD:460032
Furin-like 189..338 CDD:395614
Recep_L_domain 433..521 CDD:460032
GF_recep_IV 550..682 CDD:464344
TM_ErbB2 680..723 CDD:213055
PTKc_HER2 751..1029 CDD:270684 66/352 (19%)
Blue background indicates that the domain is not in the aligned region.

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