DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and ERBB2

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_024306409.1	Gene:	ERBB2 / 2064	HGNCID:	3430	Length:	1301	Species:	Homo sapiens

Alignment Length:	385	Identity:	109/385 - (28%)
Similarity:	173/385 - (44%)	Gaps:	69/385 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ENLVPPASGLVTLIVGGILALVL-VSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTA 297
            |....|.:.:::.:||.:|.:|| |...|||        ||....    |:..:.:||...:...
Human   691 EQRASPLTSIISAVVGILLVVVLGVVFGILI--------KRRQQK----IRKYTMRRLLQETELV 743

  Fly   298 HNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY 362
            ..   :.||...|..|.:               |.|:|..::|.:|     :..|.||.:|:|.:
Human   744 EP---LTPSGAMPNQAQM---------------RILKETELRKVKV-----LGSGAFGTVYKGIW 785

  Fly   363 -----NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFVLYA 419
                 |....|.:|.:.::.|......:|.|:.::.....|.|..:|||   |.....|..:.|.
Human   786 IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYG 850

  Fly   420 A-TGSVRNLKSFL--QDPSYARSVTTIQTVLMG--SQLAMAMEHLHNHGVIHKDIAARNCVIDDQ 479
            . ...||..:..|  ||             |:.  .|:|..|.:|.:..::|:|:||||.::...
Human   851 CLLDHVRENRGRLGSQD-------------LLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP 902

  Fly   480 LRVKLTDSALSR--DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLG 542
            ..||:||..|:|  |:...:|::  ||...||||::||::.:..:...|||||:||.:||:.|.|
Human   903 NHVKITDFGLARLLDIDETEYHA--DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG 965

  Fly   543 KLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF 602
            ..||..|...|:...|:.|.||.||..|..:::.||..||......||.|.:|   :|||
Human   966 AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFREL---VSEF 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	86/282 (30%)
		Pkinase_Tyr	343..599	CDD:285015	82/270 (30%)
ERBB2	XP_024306409.1	Recep_L_domain	52..173	CDD:307256
		Furin-like	189..384	CDD:307072
		Recep_L_domain	412..532	CDD:307256
		GF_recep_IV	557..689	CDD:317276
		TM_ErbB2	687..730	CDD:213055	14/50 (28%)
		PTKc_HER2	758..1036	CDD:270684	89/303 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900