DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and EPHB2

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_001296122.1 Gene:EPHB2 / 2048 HGNCID:3393 Length:1055 Species:Homo sapiens


Alignment Length:391 Identity:106/391 - (27%)
Similarity:178/391 - (45%) Gaps:41/391 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 GRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILA--LVLVSTLILIAYCAKGPSKRHPSNGV 279
            |.|...| |..|..|............:.||:|...|  :.|::.:::...|.:...:|..|.  
Human   515 GYGRYSG-KMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSE-- 576

  Fly   280 HLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVR 344
               .|...|...:...|....||:.|.|              ||...|......:|:.: .| |:
Human   577 ---YTDKLQHYTSGHMTPGMKIYIDPFT--------------YEDPNEAVREFAKEIDI-SC-VK 622

  Fly   345 LSCLVQEGNFGRIYRGTYN--DCQEVLV--KTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLG 405
            :..::..|.||.:..|...  ..:|:.|  ||:....::.|....|.|:.::.:..||||:.:.|
Human   623 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 687

  Fly   406 ISIEDYATPFVLYAATGSVRNLKSFLQ--DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKD 468
            :..:  :||.::........:|.|||:  |..:    |.||.|.|...:|..|::|.:...:|:|
Human   688 VVTK--STPVMIITEFMENGSLDSFLRQNDGQF----TVIQLVGMLRGIAAGMKYLADMNYVHRD 746

  Fly   469 IAARNCVIDDQLRVKLTDSALSR----DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVW 529
            :||||.:::..|..|::|..|||    |.....|.|...|:. ||:|.:.||:|...:...||||
Human   747 LAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKI-PIRWTAPEAIQYRKFTSASDVW 810

  Fly   530 SFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQ 594
            |:|::|||:.:.|:.||.::...::.:.::..|||..|.:||..|..:|..||......||.|.|
Human   811 SYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQ 875

  Fly   595 L 595
            :
Human   876 I 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745
PTK_Ryk 336..606 CDD:270639 81/270 (30%)
EPHB2NP_001296122.1 EphR_LBD_B2 19..196 CDD:198445
fn3 326..421 CDD:394996
fn3 437..520 CDD:394996 2/4 (50%)
EphA2_TM 544..617 CDD:464211 18/91 (20%)
PTKc_EphR_B 616..884 CDD:173638 81/270 (30%)
SAM_EPH-B2 910..980 CDD:188951
PDZ-binding (in isoform 2). /evidence=ECO:0000255 984..986
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 990..1055
Blue background indicates that the domain is not in the aligned region.

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