Protein Alignment drl and EPHB1

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 146/602 - (24%)
• Similarity: 244/602 - (40%)
• Gaps: 127/602 - (21%)

  Fly    58 VPVPANISDVTFTWQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGT 122
            ||....:::...:..||..| .||:.:|         :.|..:|  ...|..||  .:::..:..
Human   380 VPRQLGLTECRVSISSLWAH-TPYTFDI---------QAINGVS--SKSPFPPQ--HVSVNITTN 430

  Fly   123 RNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIH 187
            :.|..||.|..:|   .||..:..|.:.:.     |:.:....:|                 :|.
Human   431 QAAPSTVPIMHQV---SATMRSITLSWPQP-----EQPNGIILDY-----------------EIR 470

  Fly   188 YVDRNDEHVVANGHQAPEKQ--------RP-------VVTESPVGRGNSGG-------SKRDFDP 230
            |.::  ||...|...|..:.        ||       |...:..|.|...|       :..|:..
Human   471 YYEK--EHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKS 533

  Fly   231 MLRENLVPPASGLVTLIVGGILA-LVLVSTLILIA-YCAKGPSKRHPSNGVHLIKTSSFQRLPTI 293
            .|||.|        .||.|...| :|.|.:|:.|: .|::   ||..|.  ..:.:...|...|.
Human   534 ELREQL--------PLIAGSAAAGVVFVVSLVAISIVCSR---KRAYSK--EAVYSDKLQHYSTG 585

  Fly   294 SSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIY 358
            ..:....||:.|.|              ||...|......:|:.|.  .|::..::..|.||.:|
Human   586 RGSPGMKIYIDPFT--------------YEDPNEAVREFAKEIDVS--FVKIEEVIGAGEFGEVY 634

  Fly   359 RG---------TYNDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATP 414
            :|         .|     |.:||:....|:.|....|.|:.::.:..|||::.:.|:..:  :.|
Human   635 KGRLKLPGKREIY-----VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTK--SRP 692

  Fly   415 FVLYAATGSVRNLKSFLQ--DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVID 477
            .::.........|.|||:  |..:    |.||.|.|...:|..|::|.....:|:|:||||.:::
Human   693 VMIITEFMENGALDSFLRQNDGQF----TVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVN 753

  Fly   478 DQLRVKLTDSALSR----DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEM 538
            ..|..|::|..|||    |.....|.|...|:. |::|.:.||:....:...|||||:|::|||:
Human   754 SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKI-PVRWTAPEAIAYRKFTSASDVWSYGIVMWEV 817

  Fly   539 CTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFH 603
            .:.|:.||.::...::.:.::..|||..|.:||..|..:|..||......||.|:::...|.:..
Human   818 MSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMI 882

  Fly   604 TQITRYVXPAVLKHAKT 620
            ..      ||.||...|
Human   883 RN------PASLKTVAT 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	21/98 (21%)
		PTK_Ryk	336..606	CDD:270639	79/284 (28%)
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996	9/41 (22%)
		fn3	435..518	CDD:394996	20/109 (18%)
		EphA2_TM	542..616	CDD:464211	21/92 (23%)
		PTKc_EphR_B	614..882	CDD:173638	79/281 (28%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984