DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drl and EPHA8

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens


Alignment Length:610 Identity:142/610 - (23%)
Similarity:245/610 - (40%) Gaps:135/610 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LNFAVPV-PANISDVTFTWQSLVDHPLPYSIN---IATSDTEVLPRP------------------ 96
            |.:|.|: |...||:|:   :.|....|::::   ...|.|..:|:.                  
Human   346 LEWAPPLDPGGRSDITY---NAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMN 407

  Fly    97 ----ILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTIN-------VEVILDRATNNNTNLIFK 150
                |..::.:.|:..||:           |.|.|.:|.|       |.:..:||...:.:|:::
Human   408 YSFWIEAVNGVSDLSPEPR-----------RAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQ 461

  Fly   151 RKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESP 215
            ..     |:.:....||                 :|.|.:::.|      .|:....:.|.|.:.
Human   462 EP-----EQPNGIILEY-----------------EIKYYEKDKE------MQSYSTLKAVTTRAT 498

  Fly   216 VGRGNSGGSKRDFDPMLR--------ENLVPPASG--------------LVTLIVGGILALVLVS 258
            |. |...|::..|....|        ...:...:|              .:|||.|.::      
Human   499 VS-GLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVV------ 556

  Fly   259 TLILIAYCAK---GPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFR 320
             |:|:..|.|   |.||....:....:...:.|..|.:....|:     |....|.......|  
Human   557 -LLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHH-----PPGKLPEPQFYAEP-- 613

  Fly   321 EYEHEPEEFNRRLQELT--VQKCRVRLSCLVQEGNFGRIYRGTYNDCQE----VLVKTVAQHASQ 379
               |..||..|..:..|  ::..|:.:..::..|:.|.:..|......:    |.:|.:....::
Human   614 ---HTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE 675

  Fly   380 LQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL-YAATGSVRNLKSFLQDPSYARSVTTI 443
            .|....|.|:.::.:..|||::.:.|:.........|. |...||   |.:||:  ::....|.:
Human   676 RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS---LDTFLR--THDGQFTIM 735

  Fly   444 QTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR---DLFPGDYNSLGDGE 505
            |.|.|...:...|.:|.:.|.:|:|:||||.::|..|..|::|..|||   |.....|.:.| |:
Human   736 QLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG-GK 799

  Fly   506 YRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNC 570
            . ||:|.:.||:....::..||||||||:|||:...|:.||..:...::...:::||||..|..|
Human   800 I-PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGC 863

  Fly   571 PDELFTIMAYCWASMPAERPSFSQL 595
            |..|..:|..||....|:||.|||:
Human   864 PHALHQLMLDCWHKDRAQRPRFSQI 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 25/135 (19%)
PTK_Ryk 336..606 CDD:270639 81/270 (30%)
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628 39/215 (18%)
fn3 439..524 CDD:394996 18/113 (16%)
EphA2_TM <562..632 CDD:464211 16/79 (20%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 1/5 (20%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 11/64 (17%)
PTKc_EphR_A 630..896 CDD:270651 80/266 (30%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
Blue background indicates that the domain is not in the aligned region.

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