DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drl and EPHA4

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_004429.1 Gene:EPHA4 / 2043 HGNCID:3388 Length:986 Species:Homo sapiens


Alignment Length:617 Identity:135/617 - (21%)
Similarity:237/617 - (38%) Gaps:165/617 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 ATSDTEVLP------RPILNISRIGDVPV-----EPQTWG---------IALKC----------- 119
            |.:|...:|      .|:..||.:.:..|     .||..|         :..||           
Human   316 ADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPC 380

  Fly   120 -SGT-----RNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTA 178
             ||.     :|...|..:::..:|  |..|.|..|:....:       |.:....|..:.:..|.
Human   381 GSGVHYTPQQNGLKTTKVSITDLL--AHTNYTFEIWAVNGV-------SKYNPNPDQSVSVTVTT 436

  Fly   179 RKGHGGDIHYVDRND--EHVVANGHQAPEKQRPVVTESPVG------------------------ 217
            .:.....|..|...:  .:.||.....|::...|:.|..|.                        
Human   437 NQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIK 501

  Fly   218 ------------RGNSGGSKRDF-DPM-LRENLVPP------ASGLVTLI-VGG--ILALVLVST 259
                        |..:.....|| :|: :..|.||.      |:..|.|: |.|  :|.::|::.
Human   502 GLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAA 566

  Fly   260 LILIAYCAK-------GPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTR 317
            .::....:|       ...::|.:.||.                    .||.|.    ||....:
Human   567 FVISRRRSKYSKAKQEADEEKHLNQGVR--------------------TYVDPF----TYEDPNQ 607

  Fly   318 PFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY------NDCQEVLVKTVAQH 376
            ..||:..|            :....:::..::..|.||.:..|..      ..|  |.:||:...
Human   608 AVREFAKE------------IDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIC--VAIKTLKAG 658

  Fly   377 ASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL---YAATGSVRNLKSFLQ--DPSY 436
            .:..|....|.|:.::.:..|||::.:.|:..:  ..|.::   |...||   |.:||:  |..:
Human   659 YTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTK--CKPVMIITEYMENGS---LDAFLRKNDGRF 718

  Fly   437 ARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR---DLFPGDY 498
                |.||.|.|...:...|::|.:...:|:|:||||.:::..|..|::|..:||   |.....|
Human   719 ----TVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779

  Fly   499 NSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYR 563
            .:.| |:. ||:|.:.||:....:...|||||:|::|||:.:.|:.||.::...::...:::|||
Human   780 TTRG-GKI-PIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYR 842

  Fly   564 LAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595
            |..|.:||..|..:|..||....::||.|.|:
Human   843 LPPPMDCPIALHQLMLDCWQKERSDRPKFGQI 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 21/107 (20%)
PTK_Ryk 336..606 CDD:270639 77/274 (28%)
EPHA4NP_004429.1 EphR_LBD_A4 30..203 CDD:198450
FN3 329..436 CDD:238020 20/115 (17%)
FN3 441..532 CDD:238020 12/90 (13%)
EphA2_TM 562..618 CDD:464211 13/91 (14%)
PTKc_EphR_A 616..882 CDD:270651 77/272 (28%)
SAM_EPH-A4 911..981 CDD:188944
PDZ-binding. /evidence=ECO:0000255 984..986
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.