DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drl and EPHA3

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_005224.2 Gene:EPHA3 / 2042 HGNCID:3387 Length:983 Species:Homo sapiens


Alignment Length:568 Identity:133/568 - (23%)
Similarity:242/568 - (42%) Gaps:106/568 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VPVPANISDVTFTWQSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGT 122
            :|....:::.|.|...|:.| ..|:..|..            ::.:.::...|:.:         
Human   383 LPRQFGLTNTTVTVTDLLAH-TNYTFEIDA------------VNGVSELSSPPRQF--------- 425

  Fly   123 RNAEVTVTIN-------VEVILDRATNNNTNLIFKRKK----ICLREEQDSAHEEYDDDDLDLLQ 176
              |.|::|.|       :.:..||.:.|:.:|.::..:    |.|    |...:.|:..:.:...
Human   426 --AAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIIL----DYEVKYYEKQEQETSY 484

  Fly   177 TARKGHGGDIHYVDRNDEHV--------VANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLR 233
            |..:..|.::.......:.:        .|.|:....::....| ||.....||.|         
Human   485 TILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFET-SPDSFSISGES--------- 539

  Fly   234 ENLVPPASGLVTLIVGGILALVLVSTLILI---AYCAKGPSKRHPSNGVHLIKTSSFQRLPTISS 295
                   |.:|.:.:...:|::|::.:|.:   .:|  |...:|.::...|...:...:||.:.:
Human   540 -------SQVVMIAISAAVAIILLTVVIYVLIGRFC--GYKSKHGADEKRLHFGNGHLKLPGLRT 595

  Fly   296 TAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRG 360
                  ||.|.    ||...|:...|:..|.:..|     :::.|       :|..|.||.:..|
Human   596 ------YVDPH----TYEDPTQAVHEFAKELDATN-----ISIDK-------VVGAGEFGEVCSG 638

  Fly   361 TYNDCQE----VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL-YAA 420
            ......:    |.:||:....::.|....|.|:.::.:..|||::.:.|:..:......|. |..
Human   639 RLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYME 703

  Fly   421 TGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLT 485
            .||   |.|||:  .:....|.||.|.|...:|..|::|.:.|.:|:|:||||.:|:..|..|::
Human   704 NGS---LDSFLR--KHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVS 763

  Fly   486 DSALSR---DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYA 547
            |..|||   |.....|.:.| |:. ||:|.|.||:....:...|||||:|:::||:.:.|:.||.
Human   764 DFGLSRVLEDDPEAAYTTRG-GKI-PIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYW 826

  Fly   548 EIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595
            |:...::...:.:||||..|.:||..|:.:|..||......||.|.|:
Human   827 EMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQI 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 17/109 (16%)
PTK_Ryk 336..606 CDD:270639 83/268 (31%)
EPHA3NP_005224.2 EphR_LBD_A3 29..201 CDD:198449
FN3 <323..>543 CDD:442628 31/204 (15%)
FN3 437..528 CDD:238020 12/94 (13%)
EphA2_TM 555..618 CDD:464211 16/74 (22%)
PTKc_EphR_A 616..882 CDD:270651 84/278 (30%)
SAM_superfamily 912..974 CDD:472832
PDZ-binding. /evidence=ECO:0000255 981..983
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.