DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and EPHA1

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens


Alignment Length:447 Identity:121/447 - (27%)
Similarity:207/447 - (46%) Gaps:76/447 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 DIHYVDRNDEHVVANGHQAPEKQRPVVTE--------------SPVGRGNSGGSKRDFDPMLREN 235
            ::|.:::::|.     :|...:.|.::||              :|:|.|       .|.|.....
Human   482 ELHVLNQDEER-----YQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPG-------PFSPDHEFR 534

  Fly   236 LVPPAS-----GLVTLIVGGIL--ALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTI 293
            ..||.|     |.:..::.|:|  |.:|:..|:..:..|:...::.             ||....
Human   535 TSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQR-------------QRDRAT 586

  Fly   294 SSTAHNSIYVCPSTITPTYATLTRPFREYEHEPE---EFNRRLQELTVQKCRVRLSCLVQEGNFG 355
            .....:.:::.|      |..|    :.||...:   :|.|.|....:.     :..::.||.||
Human   587 DVDREDKLWLKP------YVDL----QAYEDPAQGALDFTRELDPAWLM-----VDTVIGEGEFG 636

  Fly   356 RIYRGTY----NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFV 416
            .:||||.    .||:.|.:||:...:...|....|:|:.::.:.|||::|.:.|:..:  ..|.:
Human   637 EVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTK--RKPIM 699

  Fly   417 LYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLR 481
            :.........|.:||::..  ..:...|.|.|...:|..|.:|.||..:|:|:||||.:::..|.
Human   700 IITEFMENGALDAFLRERE--DQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLC 762

  Fly   482 VKLTDSALSR--DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKL 544
            .|::|..|:|  |.|.|.|.:.| |:. ||:|.:.||:....:...|||||||::|||:.:.|..
Human   763 CKVSDFGLTRLLDDFDGTYETQG-GKI-PIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDK 825

  Fly   545 PYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSE 601
            ||.|:...|:...::|||||..|.:||..|:.:|..|||...|.||.|.:||..|.:
Human   826 PYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQ 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745
PTK_Ryk 336..606 CDD:270639 90/272 (33%)
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:394996
FN3 453..535 CDD:238020 11/64 (17%)
EphA2_TM <586..621 CDD:464211 8/44 (18%)
Protein Kinases, catalytic domain 619..884 CDD:473864 91/275 (33%)
SAM_EPH-A1 912..974 CDD:188941
PDZ-binding. /evidence=ECO:0000255 974..976
Blue background indicates that the domain is not in the aligned region.

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