Protein Alignment drl and Ryk

DIOPT Version :9

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_038677.3
• Gene: Ryk / 20187
• MGIID: 101766
• Length: 594
• Species: Mus musculus
• Alignment Length: 645
• Identity: 217/645 - (33%)
• Similarity: 335/645 - (51%)
• Gaps: 106/645 - (16%)

  Fly     3 PNLLTIGLLLTLI------------ASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALN 55
            |.||.  |||.::            |.....::::|:..||.||:|:.|||||||...|:.|||:
Mouse    19 PPLLL--LLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALS 81

  Fly    56 FAVPVPANISDVTFTW--QSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALK 118
            |.:.||:..:.:.|||  :|.|::.|.:.::    :...:..|.:|||..|:||.....:.:.|.
Mouse    82 FNLLVPSETNFLHFTWHAKSKVEYKLGFQVD----NFVAMGMPQVNISAQGEVPRTLSVFRVELS 142

  Fly   119 CSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHG 183
            |:|..::||.:.:.:.:.:: ::.|.|.|.|||:|:|.::             |:.::|:.
Mouse   143 CTGKVDSEVMILMQLNLTVN-SSKNFTVLNFKRRKMCYKK-------------LEEVKTSA---- 189

  Fly   184 GDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIV 248
                 :|:|....:                              :||:   :..|..|..|..|.
Mouse   190 -----LDKNTSRTI------------------------------YDPV---HAAPTTSTRVFYIS 216

  Fly   249 GGILALVLVSTLILIAYCAKGPSKR----------HPSNGVHLIKTSSFQRLPTISSTAHNSIYV 303
            .|:...|:....|::|.......||          ..|.|:....|.:.|.|.  :.|.:|:..:
Mouse   217 VGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLR--ADTPNNATPI 279

  Fly   304 CPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY------ 362
            ..|:..||........|..  ...|...:::::.:.:.|:.|..::|||.||||:.|..
Mouse   280 TSSSGYPTLRIEKNDLRSV--TLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILVDEKDP 342

  Fly   363 NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL--YAATGSVR 425
            |..::..||||...||::||.::|.||..|....|.|:|.:..:.||:...|.|:  |...|
Mouse   343 NKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWG--- 404

  Fly   426 NLKSFLQ-----DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLT 485
            |||.||:     :.:..::::....|.|..|:|..|.:|....|||:|:|||||||||.|:||:|
Mouse   405 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKIT 469

  Fly   486 DSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEID 550
            |:||||||||.||:.|||.|.||::|::||:|..:.::..||||:|||.:||:.|||:.||.:||
Mouse   470 DNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 534

  Fly   551 PYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            |:||..|||||||:|||.|||||||.:||.|||..|.|||.|.||..||:|||..:..||
Mouse   535 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	46/137 (34%)
		PTK_Ryk	336..606	CDD:270639	134/282 (48%)
		Pkinase_Tyr	343..599	CDD:285015	128/268 (48%)
Ryk	NP_038677.3	WIF	47..180	CDD:128745	46/137 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..283		7/34 (21%)
		PTK_Ryk	310..590	CDD:270639	134/282 (48%)
		Pkinase_Tyr	317..583	CDD:285015	128/268 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1833
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2184
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	1	1.010	-	-		QHG45854
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm43395
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3316
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.810