DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and EPHA2

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:XP_054190833.1 Gene:EPHA2 / 1969 HGNCID:3386 Length:978 Species:Homo sapiens


Alignment Length:439 Identity:124/439 - (28%)
Similarity:202/439 - (46%) Gaps:63/439 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 TARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSK-RDFDPMLRENLVPPA 240
            |.||....:.:.|.|.:...|.....||:....|..::....|...||| .:|     :.|.|..
Human   474 TYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEF-----QTLSPEG 533

  Fly   241 SGLVTLI----VGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSI 301
            ||.:.:|    ||.:|.|||......|....|....|.....|:..|:...:.|.|         
Human   534 SGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKT--------- 589

  Fly   302 YVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQE-----GNFGRIYRG- 360
            ||.|                  |..|:.|:.:.:.|.:   :..||:.::     |.||.:|:| 
Human   590 YVDP------------------HTYEDPNQAVLKFTTE---IHPSCVTRQKVIGAGEFGEVYKGM 633

  Fly   361 --TYNDCQE--VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL--YA 419
              |.:..:|  |.:||:....::.|....|.|:.::.:.||.|::.:.|: |..|....::  |.
Human   634 LKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGV-ISKYKPMMIITEYM 697

  Fly   420 ATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKL 484
            ..|:   |..||::.....||..:..:|.|  :|..|::|.|...:|:|:||||.:::..|..|:
Human   698 ENGA---LDKFLREKDGEFSVLQLVGMLRG--IAAGMKYLANMNYVHRDLAARNILVNSNLVCKV 757

  Fly   485 TDSALSR---DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546
            :|..|||   |.....|.:.| |:. ||:|.:.||:....:...|||||||::|||:.|.|:.||
Human   758 SDFGLSRVLEDDPEATYTTSG-GKI-PIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPY 820

  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595
            .|:..:|:...:.||:||..|.:||..::.:|..||....|.||.|:.:
Human   821 WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADI 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745
PTK_Ryk 336..606 CDD:270639 86/275 (31%)
EPHA2XP_054190833.1 EphR_LBD_A2 30..203 CDD:198448
fn3 332..426 CDD:394996
fn3 440..521 CDD:394996 10/46 (22%)
EphA2_TM <558..612 CDD:464211 14/83 (17%)
PTKc_EphR_A2 609..877 CDD:133194 85/272 (31%)
SAM_EPH-A2 904..973 CDD:188942
Blue background indicates that the domain is not in the aligned region.

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