Protein Alignment drl and lin-18

DIOPT Version :9

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_508684.4
• Gene: lin-18 / 180679
• WormBaseID: WBGene00003007
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 658
• Identity: 190/658 - (28%)
• Similarity: 299/658 - (45%)
• Gaps: 159/658 - (24%)

  Fly    20 AHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTFTWQSL-VDHPLPYSI 83
            |::|:|::..|:.|..||.|||.|:..|.::.|:..|...|.|||..::|||.:: :.|   |.:
 Worm    18 ANVNMFISKEEMNRTFGVKAELNYIEMGNVSSYSTKFHYRVMANIDYLSFTWNAVGIVH---YEV 79

  Fly    84 NIATSDTEVLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTI-------NVEVILDRAT 141
            .:.:.|:.||  ||:.|...|.||...|.:.:..:|:|.|:.:..|::       |.|.:
 Worm    80 YVESDDSSVL--PIVRIPLKGTVPESLQDFTVEYRCAGHRSGQFAVSLYFTFKYGNKEPL----- 137

  Fly   142 NNNTNLIFKRKKICL----REEQDSAHEEYDDDDLD-----------------LLQTARKGHGGD 185
                .:..:::|||.    |...:..:|.::.||.|                 |:..|..
 Worm   138 ----KVKLRQEKICASRDGRRGLNGGYEGHEVDDTDSIDKAFFVIICIAAAFLLIVAATL----- 193

  Fly   186 IHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGG 250
            |.|..|:            :|:..:.|..|....||..|.:...|.|   |..|..|..||
 Worm   194 ICYFKRS------------KKEDMIPTRLPTSFRNSLKSTKSAQPFL---LSTPRDGPPTL---- 239

  Fly   251 ILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATL 315
                    :.|..|.|:.                         ||.:.|||  .||  .|....:
 Worm   240 --------SAISSAPCSS-------------------------SSASGNSI--IPS--KPRNIDV 267

  Fly   316 TRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVL----------- 369
            .|...:...:.:.|    |.|.          |..||.||.:....:....:||
 Worm   268 RRALLQLYQDRDAF----QSLP----------LDMEGTFGEVRYAIWRQVDDVLNGDVDDEEDTF 318

  Fly   370 -------VKTVAQHASQLQVNLLLQESMMLYEAS-HPNVLSVLGI----------SIEDYATPFV 416
                   .||:..:||.:|::..|.::::.|..: |.|:..|..:          ::.|:  |.|
 Worm   319 CNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVASFGRFDRPETVTDF--PLV 381

  Fly   417 LYAATGSVRNLKSFL------QDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCV 475
            .|...| ..|||.||      .....|:::.|.|.|.:.:|::.|:.|:|.:.::|.|||||||:
 Worm   382 CYRHQG-FGNLKKFLTICRHGDKTKGAQTLRTHQLVSLATQVSSAVAHIHKYRIVHNDIAARNCL 445

  Fly   476 I---DDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWE 537
            |   :.:|:|:|.||||||||||.||:.|||.|.||:||:|.||:....|:..:||||.|||:||
 Worm   446 IAEVNGRLQVQLCDSALSRDLFPADYHCLGDNENRPLKWMSPEAIANELYSSAADVWSLGVLLWE 510

  Fly   538 MCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF 602
            :.:||..|:|||||.|:...:..|.||.||.||||:|:.:|..||..:..:|||..|:...|.:|
 Worm   511 LMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVMLCCWRVLSEDRPSSEQVVHGLRDF 575

  Fly   603 HTQITRYV 610
            :.|:::|:
 Worm   576 NIQLSQYI 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	41/147 (28%)
		PTK_Ryk	336..606	CDD:270639	109/307 (36%)
		Pkinase_Tyr	343..599	CDD:285015	106/293 (36%)
lin-18	NP_508684.4	WIF	19..149	CDD:128745	41/143 (29%)
		PTK_Ryk	274..579	CDD:270639	111/321 (35%)
		Pkinase_Tyr	289..572	CDD:285015	105/285 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I1974
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I1880
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	1	1.010	-	-		QHG45854
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm14716
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3316
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.760