DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and Insr

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_001316985.1 Gene:Insr / 16337 MGIID:96575 Length:1384 Species:Mus musculus


Alignment Length:586 Identity:142/586 - (24%)
Similarity:245/586 - (41%) Gaps:120/586 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 ISDVTFTWQSLVDHPLPYSINIATSDTE------VLPRPILNISRI--------------GDVPV 108
            :.:||.|..:|.|.|...|..:.||..|      |:.:..|.||.:              .|.|.
Mouse   769 VGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPD 833

  Fly   109 EPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQ-----------DS 162
            |        :||..  |.|:.....|...|......|:.||:...:.|..::           :.
Mouse   834 E--------RCSVA--AYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEV 888

  Fly   163 AHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGN------- 220
            ::..|.|::|.|                     .|:..|.|.|:...:...||   ||       
Mouse   889 SYRRYGDEELHL---------------------CVSRKHFALERGCRLRGLSP---GNYSVRVRA 929

  Fly   221 ----SGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHL 281
                ..||..:.......:.:...|.:..:|:|.::.:.|.|.:|...|...  .||.|...:..
Mouse   930 TSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFL--RKRQPDGPMGP 992

  Fly   282 IKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLS 346
            :..||.....:.|....:|:||                      |:|:.       |.:.::.|.
Mouse   993 LYASSNPEYLSASDVFPSSVYV----------------------PDEWE-------VPREKITLL 1028

  Fly   347 CLVQEGNFGRIYRGTYNDC------QEVLVKTVAQHAS-QLQVNLLLQESMMLYEASHPNVLSVL 404
            ..:.:|:||.:|.|...|.      ..|.||||.:.|| :.::..|.:.|:|.....| :|:.:|
Mouse  1029 RELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLL 1092

  Fly   405 GISIEDYATPFVL-YAATGSVR-NLKSFLQDP--SYARSVTTIQTVL-MGSQLAMAMEHLHNHGV 464
            |:..:...|..|: ..|.|.:: :|:|...|.  :..|...|:|.:: |.:::|..|.:|:....
Mouse  1093 GVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKF 1157

  Fly   465 IHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVW 529
            :|:|:|||||::.....||:.|..::||::..||...|.....|::|:|.|:|:...:...||:|
Mouse  1158 VHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMW 1222

  Fly   530 SFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQ 594
            ||||::||:.:|.:.||..:...::..::.||..|..|.|||:.|..:|..||...|..||:|.:
Mouse  1223 SFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLE 1287

  Fly   595 L 595
            :
Mouse  1288 I 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 26/112 (23%)
PTK_Ryk 336..606 CDD:270639 83/272 (31%)
InsrNP_001316985.1 Recep_L_domain 52..164 CDD:460032
Furin-like 179..337 CDD:395614
Recep_L_domain 359..472 CDD:460032
FN3 <584..>660 CDD:442628
FN3 624..>667 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..709
Insulin-binding. /evidence=ECO:0000250 735..743
FN3 869..946 CDD:238020 15/100 (15%)
Insulin_TMD 942..989 CDD:465543 10/48 (21%)
Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250 998..1001 0/2 (0%)
PTKc_InsR 1018..1305 CDD:133192 83/279 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1361..1384
PIK3R1 binding. /evidence=ECO:0000250 1363..1366
Blue background indicates that the domain is not in the aligned region.

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