Protein Alignment drl and Fgfr2

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_034337.2
• Gene: Fgfr2 / 14183
• MGIID: 95523
• Length: 840
• Species: Mus musculus
• Alignment Length: 594
• Identity: 157/594 - (26%)
• Similarity: 250/594 - (42%)
• Gaps: 143/594 - (24%)

  Fly   102 RIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLRE-EQDSAHE 165
            |||...|..|.|.:.:                |.::.....|.|         ||.| |..|.:.
Mouse   222 RIGGYKVRNQHWSLIM----------------ESVVPSDKGNYT---------CLVENEYGSINH 261

  Fly   166 EYDDDDLD------LLQTARKGH-----GGDIHYVDR--ND--------EHVVANGHQ------- 202
            .|..|.::      :||.....:     |||:.:|.:  :|        :||..||.:
Mouse   262 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLP 326

  Fly   203 -----------APEKQRPV-----VTESPVGR-----GNSGGSK------RDFDPMLRENLVPPA 240
                       ..:|:..|     ||....|.     |||.|..      ......:||..:..:
Mouse   327 YLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPVREKEITAS 391

  Fly   241 SGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHP----SNGVH-LIKTSSFQRLPTISSTAHNS 300
            ...:.:.:..|...::...::.:.:|....:.:.|    ...|| |.|....:|..|:|:.:.:|
Mouse   392 PDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSS 456

  Fly   301 IYVCPSTITPTYATLTR-------PF----REYE--HEPE-EFNRRLQELTVQKCRVRLSCLVQE 351
            :    ::.||.....||       |.    .|||  .:|: ||.|  .:||:.|       .:.|
Mouse   457 M----NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPR--DKLTLGK-------PLGE 508

  Fly   352 GNFGRIY--------RGTYNDCQEVLVKTVAQHASQLQVNLLLQE-SMMLYEASHPNVLSVLGIS 407
            |.||::.        :....:...|.||.:...|::..::.|:.| .||.....|.|::::||..
Mouse   509 GCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGAC 573

  Fly   408 IED---YATPFVLYAATGSVRNLKSFLQ-------DPSY------ARSVTTIQTVLMGSQLAMAM 456
            .:|   |.  .|.||:.|   ||:.:|:       :.||      ...:|....|....|||..|
Mouse   574 TQDGPLYV--IVEYASKG---NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 633

  Fly   457 EHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSH 521
            |:|.:...||:|:||||.::.:...:|:.|..|:||:...||.........|:||::.|||....
Mouse   634 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 698

  Fly   522 YNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMP 586
            |...||||||||||||:.|||..||..|...|:...||:|:|:.:|.||.:||:.:|..||.::|
Mouse   699 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVP 763

  Fly   587 AERPSFSQL 595
            ::||:|.||
Mouse   764 SQRPTFKQL 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	10/54 (19%)
		PTK_Ryk	336..606	CDD:270639	96/285 (34%)
Fgfr2	NP_034337.2	Ig	50..143	CDD:472250
		Ig strand B	77..81	CDD:409353
		Ig strand C	88..92	CDD:409353
		Ig strand E	109..113	CDD:409353
		Ig strand F	123..128	CDD:409353
		Ig strand G	136..139	CDD:409353
		IgI_2_FGFR	173..267	CDD:409443	15/69 (22%)
		Ig strand A	173..176	CDD:409443
		Ig strand A'	184..189	CDD:409443
		Ig strand B	193..201	CDD:409443
		Ig strand C	207..212	CDD:409443
		Ig strand C'	215..217	CDD:409443
		Ig strand D	226..229	CDD:409443	0/2 (0%)
		Ig strand E	233..238	CDD:409443	1/20 (5%)
		Ig strand F	247..254	CDD:409443	4/15 (27%)
		Ig strand G	257..267	CDD:409443	2/9 (22%)
		IgI_3_FGFR2	275..379	CDD:409444	20/103 (19%)
		Ig strand A	275..278	CDD:409444	0/2 (0%)
		Ig strand A'	282..286	CDD:409444	0/3 (0%)
		Ig strand B	294..301	CDD:409444	1/6 (17%)
		Ig strand C	305..312	CDD:409444	0/6 (0%)
		Ig strand D	327..332	CDD:409444	0/4 (0%)
		Ig strand E	344..349	CDD:409444	1/4 (25%)
		Ig strand F	357..365	CDD:409444	1/7 (14%)
		Ig strand G	368..376	CDD:409444	1/7 (14%)
		PTKc_FGFR2	475..787	CDD:270679	104/312 (33%)