Protein Alignment drl and Ryk

DIOPT Version :9

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_536327.1
• Gene: Ryk / 140585
• RGDID: 620549
• Length: 594
• Species: Rattus norvegicus
• Alignment Length: 645
• Identity: 220/645 - (34%)
• Similarity: 335/645 - (51%)
• Gaps: 106/645 - (16%)

  Fly     3 PNLLTIGLLLTLI------------ASGQAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALN 55
            |.||.  |||.::            |.....::::|:..||.||:|:.|||||||...|:.|||:
  Rat    19 PPLLL--LLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALS 81

  Fly    56 FAVPVPANISDVTFTW--QSLVDHPLPYSINIATSDTEVLPRPILNISRIGDVPVEPQTWGIALK 118
            |.:.||:..:.:.|||  :|.|::.|.:.::    :...:..|.:|||..|:||.....:.:.|.
  Rat    82 FNLLVPSETNFLHFTWHAKSKVEYKLGFQVD----NFVAMGMPQVNISAQGEVPRTLSVFRVELS 142

  Fly   119 CSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHG 183
            |:|..::||.:.:.:.:.:: ::.|.|.|.|||:|:|.::             |:.::|:.
  Rat   143 CTGKVDSEVMILMQLNLTVN-SSKNFTVLNFKRRKMCYKK-------------LEEVKTSA---- 189

  Fly   184 GDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIV 248
                 :|:|....:                              :||:   :..|..|..|..|.
  Rat   190 -----LDKNTSRTI------------------------------YDPV---HAAPTTSTRVFYIS 216

  Fly   249 GGILALVLVSTLILIAYCAKGPSKR----------HPSNGVHLIKTSSFQRLPTISSTAHNSIYV 303
            .|:...|:....|::|.......||          ..|.|:....|.:.|.|.  :.|.:|:..|
  Rat   217 VGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLR--ADTPNNATPV 279

  Fly   304 CPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY------ 362
            ..|:..||........|..  ...|...:::::.:.:.||.|..::|||.||||:.|..
  Rat   280 TSSSGYPTLRIEKNDLRSV--TLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDP 342

  Fly   363 NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL--YAATGSVR 425
            |..::..||||...||::||.::|.||..|....|.|:|.:..:.||:...|.|:  |...|
  Rat   343 NKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVISPYMNWG--- 404

  Fly   426 NLKSFLQ-----DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLT 485
            |||.||:     :.:..::::....|.|..|:|..|.:|....|||||:|||||||||.|:||:|
  Rat   405 NLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKIT 469

  Fly   486 DSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEID 550
            |:||||||||.||:.|||.|.||::|::||:|..:.::..||||:|||.:||:.|||:.||.:||
  Rat   470 DNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDID 534

  Fly   551 PYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            |:||..|||||||:|||.|||||||.:||.|||..|.|||.|.||..||:|||..:..||
  Rat   535 PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	46/137 (34%)
		PTK_Ryk	336..606	CDD:270639	136/282 (48%)
		Pkinase_Tyr	343..599	CDD:285015	130/268 (49%)
Ryk	NP_536327.1	WIF	47..180	CDD:128745	46/137 (34%)
		PTK_Ryk	310..590	CDD:270639	136/282 (48%)
		Pkinase_Tyr	317..583	CDD:285015	130/268 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1758
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2121
OMA	1	1.010	-	-		QHG45854
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm45465
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840