DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and Erbb2

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001003817.1	Gene:	Erbb2 / 13866	MGIID:	95410	Length:	1256	Species:	Mus musculus

Alignment Length:	685	Identity:	162/685 - (23%)
Similarity:	253/685 - (36%)	Gaps:	192/685 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ASGQA-----HLNIFLNLHEVLRLIGVSA------------ELYYVREGAINDYALNFAVPVPAN 63
            :||.|     ||.:|..|.|:...:.:||            .|..:|...::|.|
Mouse   387 SSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGA---------- 441

  Fly    64 ISDVTFTWQSLVDHPLPYS--------------------INIATSDTEVLPRPILNISRIGDVPV 108
               .:.|.|.|..|.|...                    :|....| ::...|...:...|:.|.
Mouse   442 ---YSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWD-QLFRNPHQALLHSGNRPE 502

  Fly   109 EP---------------QTWG----IALKCSG-TRNAEVTVTINVEVILDRATNNNTNLIFKRKK 153
            |.               ..||    ..:.||. .|..|......|...|.|.        :.|.|
Mouse   503 EACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPRE--------YVRGK 559

  Fly   154 ICLR-----EEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTE 213
            .||.     :.|:|:...| ..:.|..:..       .||.|.:.  .||   :.|...:|.::.
Mouse   560 HCLPCHPECQPQNSSETCY-GSEADQCEAC-------AHYKDSSS--CVA---RCPSGVKPDLSY 611

  Fly   214 SPVGRG------------NSGGSKRDFD----PMLRENLVPPASGLVTLIVGGILALVLVSTL-I 261
            .|:.:.            |...|..|.|    |  .|....|.:.::..:||.:|.|::|..: |
Mouse   612 MPIWKYPDEEGICQPCPINCTHSCVDLDERGCP--AEQRASPVTFIIATVVGVLLFLIIVVVIGI 674

  Fly   262 LIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEP 326
            ||        ||....    |:..:.:||...:.....   :.||...|..|.:
Mouse   675 LI--------KRRRQK----IRKYTMRRLLQETELVEP---LTPSGAVPNQAQM----------- 713

  Fly   327 EEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTY-----NDCQEVLVKTVAQHASQLQVNLLL 386
                |.|:|..::|.:|     :..|.||.:|:|.:     |....|.:|.:.::.|......:|
Mouse   714 ----RILKETELRKLKV-----LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL 769

  Fly   387 QESMMLYEASHPNVLSVLGI---SIEDYATPFVLYAA-TGSVRNLKSFLQDPSYARSVTTIQTVL 447
            .|:.::.....|.|..:|||   |.....|..:.|.. ...||..:..|
Mouse   770 DEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRL---------------- 818

  Fly   448 MGS--------QLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR--DLFPGDYNSLG 502
             ||        |:|..|.:|....::|:|:||||.::.....||:||..|:|  |:...:|::
Mouse   819 -GSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHA-- 880

  Fly   503 DGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQP 567
            ||...||||::||::.:..:...|||||:||.:||:.|.|..||..|...|:...|:.|.||.||
Mouse   881 DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQP 945

  Fly   568 FNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF 602
            ..|..:::.||..||......||.|.:|   :|||
Mouse   946 PICTIDVYMIMVKCWMIDSECRPRFREL---VSEF 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	34/187 (18%)
		PTK_Ryk	336..606	CDD:270639	85/286 (30%)
		Pkinase_Tyr	343..599	CDD:285015	81/274 (30%)
Erbb2	NP_001003817.1	Recep_L_domain	52..174	CDD:279382
		Furin-like	190..339	CDD:279142
		FU	236..281	CDD:238021
		Recep_L_domain	367..487	CDD:279382	21/113 (19%)
		GF_recep_IV	511..644	CDD:291509	29/153 (19%)
		FU	512..>545	CDD:238021	6/32 (19%)
		FU	558..604	CDD:214589	13/58 (22%)
		TM_ErbB2	642..685	CDD:213055	14/56 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	677..690		3/16 (19%)
		Required for interaction with KPNB1 and EEA1. /evidence=ECO:0000250	677..690		3/16 (19%)
		PTKc_HER2	713..991	CDD:270684	88/307 (29%)
		Pkinase_Tyr	721..977	CDD:285015	83/282 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1180
		Interaction with PIK3C2B. /evidence=ECO:0000250	1196..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1224..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900