DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and Epha8

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_031965.2 Gene:Epha8 / 13842 MGIID:109378 Length:1004 Species:Mus musculus


Alignment Length:653 Identity:148/653 - (22%)
Similarity:255/653 - (39%) Gaps:163/653 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LNFAVPV-PANISDVTFTWQSLVDHPLPYSIN---IATSDTEVLPRP------------------ 96
            |.:|.|: |...||:|:   :.|....|::::   ...|.|..:|:.                  
Mouse   345 LEWAPPLDPGGRSDITY---NAVCRRCPWALSHCEACGSGTRFVPQQTSLAQASLLVANLLAHMN 406

  Fly    97 ----ILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTIN-------VEVILDRATNNNTNLIFK 150
                |..::.:.::..||::           .|.|.:|.|       |.:..:||...:.:|:::
Mouse   407 YSFWIEAVNGVSNLSPEPRS-----------AAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQ 460

  Fly   151 RKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESP 215
            ..     |:.:....||                 :|.|.:::.|      .|:....:.|.|.:.
Mouse   461 EP-----EQPNGIILEY-----------------EIKYYEKDKE------MQSYSTLKAVTTRAT 497

  Fly   216 VGRGNSGGSKRDFDPMLR--------ENLVPPASG--------------LVTLIVGGILALVLVS 258
            |. |...|::..|....|        ...:...:|              .:|||.|.::      
Mouse   498 VS-GLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVV------ 555

  Fly   259 TLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRP----- 318
             |:|:..|    .|||..      .:.:||     .|......|.......|.:..|..|     
Mouse   556 -LLLLLIC----KKRHCG------YSKAFQ-----DSDEEKMHYQNGQAPPPVFLPLNHPPGKFP 604

  Fly   319 ---FREYEHEPEEFNRRLQELT--VQKCRVRLSCLVQEGNFGRIYRGTYNDCQ-------EVLVK 371
               |....|..||..|..:..|  ::..|:.:..::..|..|.:   .|...|       .|.:|
Mouse   605 ETQFSAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEV---CYGRLQVPGQRDVPVAIK 666

  Fly   372 TVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL-YAATGSVRNLKSFLQDPS 435
            .:....::.|....|.|:.::.:..|||::.:.|:.........|. |...||   |.:||:  :
Mouse   667 ALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS---LDAFLR--T 726

  Fly   436 YARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLF---PGD 497
            :....|.:|.|.|...:...|.:|.:.|.||:|:||||.::|.:|..|::|..|||.|.   ...
Mouse   727 HDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAA 791

  Fly   498 YNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGY 562
            |.:.| |:. ||:|.:.||:....::..||||||||:|||:...|:.||..:...::...:::||
Mouse   792 YTTAG-GKI-PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGY 854

  Fly   563 RLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF-HT--------QITRYVXPAVLKHA 618
            ||..|..||..|..:|..||....|:||.|:.:...|... |:        .::|.. ||   .|
Mouse   855 RLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPA---FA 916

  Fly   619 KTC 621
            ::|
Mouse   917 RSC 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 23/135 (17%)
PTK_Ryk 336..606 CDD:270639 83/291 (29%)
Epha8NP_031965.2 EphR_LBD_A8 30..202 CDD:198454
FN3 <325..>518 CDD:442628 37/215 (17%)
FN3 439..530 CDD:238020 18/119 (15%)
EphA2_TM <561..631 CDD:464211 17/84 (20%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000269|PubMed:17875921 563..569 3/11 (27%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000269|PubMed:11416136 588..643 10/54 (19%)
Protein Kinases, catalytic domain 629..895 CDD:473864 81/275 (29%)
SAM_EPH-A8 932..994 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1002..1004
Blue background indicates that the domain is not in the aligned region.

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