DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and Egfr

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_997538.1	Gene:	Egfr / 13649	MGIID:	95294	Length:	1210	Species:	Mus musculus

Alignment Length:	389	Identity:	102/389 - (26%)
Similarity:	171/389 - (43%)	Gaps:	66/389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRL--------PTIS 294
            |....:.|.||||:|.:|:|:..|       |...|..    |:::..:.:||        |
Mouse   643 PKIPSIATGIVGGLLFIVVVALGI-------GLFMRRR----HIVRKRTLRRLLQERELVEP--- 693

  Fly   295 STAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYR 359
                    :.||...|..|.|               |.|:|...:|.:|     :..|.||.:|:
Mouse   694 --------LTPSGEAPNQAHL---------------RILKETEFKKIKV-----LGSGAFGTVYK 730

  Fly   360 GTYNDCQE-----VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFV 416
            |.:....|     |.:|.:.:..|......:|.|:.::....:|:|..:|||   |.....|..:
Mouse   731 GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLM 795

  Fly   417 LYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLR 481
            .|..      |..::::  :..::.:...:....|:|..|.:|.:..::|:|:||||.::.....
Mouse   796 PYGC------LLDYVRE--HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 852

  Fly   482 VKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546
            ||:||..|::.|...:.....:|...||||::||::....|...|||||:||.:||:.|.|..||
Mouse   853 VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 917

  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            ..|...::...|:.|.||.||..|..:::.||..||......||.|.:|.:..|:......||:
Mouse   918 DGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYL 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	76/277 (27%)
		Pkinase_Tyr	343..599	CDD:285015	74/263 (28%)
Egfr	NP_997538.1	Recep_L_domain	57..168	CDD:279382
		Approximate	75..300
		Furin-like	184..335	CDD:279142
		FU	231..274	CDD:238021
		Recep_L_domain	362..481	CDD:279382
		Approximate	390..600
		GF_recep_IV	505..636	CDD:291509
		FU	506..559	CDD:238021
		FU	552..598	CDD:214589
		TM_ErbB1	634..679	CDD:213054	13/46 (28%)
		Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250	690..706		5/26 (19%)
		PTKc_EGFR	706..1018	CDD:270683	82/304 (27%)
		TyrKc	715..970	CDD:197581	75/267 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1137
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900