DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and Egfr

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:NP_997538.1 Gene:Egfr / 13649 MGIID:95294 Length:1210 Species:Mus musculus


Alignment Length:389 Identity:102/389 - (26%)
Similarity:171/389 - (43%) Gaps:66/389 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 PPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRL--------PTIS 294
            |....:.|.||||:|.:|:|:..|       |...|..    |:::..:.:||        |   
Mouse   643 PKIPSIATGIVGGLLFIVVVALGI-------GLFMRRR----HIVRKRTLRRLLQERELVEP--- 693

  Fly   295 STAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYR 359
                    :.||...|..|.|               |.|:|...:|.:|     :..|.||.:|:
Mouse   694 --------LTPSGEAPNQAHL---------------RILKETEFKKIKV-----LGSGAFGTVYK 730

  Fly   360 GTYNDCQE-----VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFV 416
            |.:....|     |.:|.:.:..|......:|.|:.::....:|:|..:|||   |.....|..:
Mouse   731 GLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLM 795

  Fly   417 LYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLR 481
            .|..      |..::::  :..::.:...:....|:|..|.:|.:..::|:|:||||.::.....
Mouse   796 PYGC------LLDYVRE--HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 852

  Fly   482 VKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPY 546
            ||:||..|::.|...:.....:|...||||::||::....|...|||||:||.:||:.|.|..||
Mouse   853 VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 917

  Fly   547 AEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            ..|...::...|:.|.||.||..|..:::.||..||......||.|.:|.:..|:......||:
Mouse   918 DGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYL 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745
PTK_Ryk 336..606 CDD:270639 76/277 (27%)
EgfrNP_997538.1 Recep_L_domain 57..168 CDD:460032
Approximate 75..300
Furin-like 184..335 CDD:395614
Recep_L_domain 362..481 CDD:460032
Approximate 390..600
GF_recep_IV 505..636 CDD:464344
TM_ErbB1 634..679 CDD:213054 13/46 (28%)
Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250 690..706 5/26 (19%)
PTKc_EGFR 706..1018 CDD:270683 82/304 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1137
Blue background indicates that the domain is not in the aligned region.

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