Protein Alignment drl and Drl-2

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_061501118.1
• Gene: Drl-2 / 1277016
• VectorBaseID: AGAMI1_004504
• Length: 636
• Species: Anopheles gambiae
• Alignment Length: 687
• Identity: 228/687 - (33%)
• Similarity: 330/687 - (48%)
• Gaps: 155/687 - (22%)

  Fly    10 LLLTLIASG-----QAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISDVTF 69
            ||:|::..|     ..:.::|||..||::|:|:.|:|:|||:|||||||::|.||:...|..:.|
Mosquito    19 LLVTVLLCGLPPPVTGYFDLFLNHSEVIKLMGIEADLFYVRDGAINDYAMSFVVPMKPGIDFLRF 83

  Fly    70 TWQSLVDHPLPYSINIATSDTE-VLPRPILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTINV 133
            :|||...:||||:|::...|.| .|..|.|:|...|.:|:..:::.:.|.|.|....||.|.|::
Mosquito    84 SWQSRTTYPLPYTISVHYDDNEGALQHPELDIPSSGIIPMTVESFTVHLVCWGNVTKEVPVGIHL 148

  Fly   134 EVILDRATNNNTNLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVA 198
            .| .....:|:|.||.||.|||:                       ||    :|
Mosquito   149 HV-EGPPKHNDTKLIIKRNKICI-----------------------KG----MH----------- 174

  Fly   199 NGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILI 263
                 |.:.|....|....:|                  |...|.....:|.:|.:.|:::.:.:
Mosquito   175 -----PARNRLPAAEIAPQQG------------------PALLGAAACALGLVLVVGLIASAMYV 216

  Fly   264 -------------------------AYCAKGPSKRHPS--NGVHLI------------KTSSFQR 289
                                     .:....|..|.||  :|.:..            |.|.|:.
Mosquito   217 RARKQIRQDSLHTSFTTAAYGSHQNVFIRLDPLGRPPSANSGSYATIASLNKYPISESKKSWFRS 281

  Fly   290 LPTIS---------------STAHNSIY-----VCPSTI--------TPTYATLTRPFREYEHEP 326
            .|:.|               .|...|:|     ||||.:        |..| :|:.|.|......
Mosquito   282 TPSPSPYATALLPLGQNGTAGTGTESVYAKPESVCPSRVSYYASSQLTQVY-SLSTPARSIHSNG 345

  Fly   327 EEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYN----DCQEVLVKTVAQHASQLQVNLLLQ 387
            .....:|:.:.|....:....|||||.:||||.|..:    :.::||:|||...||..||..||.
Mosquito   346 SNPKDKLRRIAVSPGTILCQQLVQEGTYGRIYSGILHHPLGETRDVLIKTVVDGASLSQVAYLLS 410

  Fly   388 ESMMLYEASHPNVLSVLGISIEDYATPFVLY--AATGSVRNLKSFLQDPSYARSV-------TTI 443
            |...|...||||:|..:....|....|.|.|  ||.|   |||.:||.   .|.:       :|.
Mosquito   411 EGSTLCGISHPNILFPVAAVTELSGPPKVAYPLAAKG---NLKLYLQS---CREIGIQNSQLSTR 469

  Fly   444 QTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRP 508
            |.|..|.|:|..:.|||:.||:|||||.||||:|.:|.|::.|:|||||:||.||:.|||.|.||
Mosquito   470 QLVEFGLQVARGISHLHSLGVLHKDIATRNCVLDVELNVRVCDNALSRDVFPSDYHCLGDNENRP 534

  Fly   509 IKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDE 573
            |||::||.|:|..:...||:||.|||:||:.||..:|:.|:|.:|:..||:||||||||.|||||
Mosquito   535 IKWMALETLEKKFFTASSDIWSLGVLLWELATLAAMPFEEVDCFELSAYLRDGYRLAQPVNCPDE 599

  Fly   574 LFTIMAYCWASMPAERPSFSQLQICLSEFHTQITRYV 610
            .:|:|:.||.:...:||||.||...|.:||..:.:|:
Mosquito   600 FYTVMSCCWLADYKQRPSFPQLIAYLHDFHDDLGKYI 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	57/136 (42%)
		PTK_Ryk	336..606	CDD:270639	131/282 (46%)
Drl-2	XP_061501118.1	None