Protein Alignment drl and MERTK

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_006334.2
• Gene: MERTK / 10461
• HGNCID: 7027
• Length: 999
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 65/338 - (19%)
• Similarity: 109/338 - (32%)
• Gaps: 121/338 - (35%)

  Fly   261 RWANWEFHMSFDVRAGLVISLASIFDMDMNRYRQVLYKGHLSEMFVPYMDPNDDWYFISYLD--C 323
            ||.|..           .:..||.||:.           .|..:.:....|.|       :|  |
Human   147 RWTNMN-----------ALHYASYFDVP-----------ELIRVILKTSKPKD-------VDATC 182

  Fly   324 GEFGCGQTAVSLEPYTDCP----------PNAAFMDG-------IFPGQDGTPTKISNVMCIFEK 371
            .:|..| ||:.:..:..|.          .|.||.:.       :.|.....|.::::...|
Human   183 SDFNFG-TALHIAAHNLCAGAVKTLLELGANPAFRNDKGQIPAEVVPDPVDMPLEMADAAAI--- 243

  Fly   372 YAGDIMWRHTEA-EVPGLKITEVRP--DVSLVARMVTTVGNYDYIIEYEFKPSGSIKMG--VGLT 431
             |.:|.....:| .:|......|.|  |.:....|:|::|               :|:|  |.:.
Human   244 -AKEIKQMLLDAVPLPCTSAKAVLPNSDHTTSRAMLTSLG---------------LKLGDRVVIA 292

  Fly   432 GVLEVKPVEYVHTSEIKEDDIYGTIVADNTVGVNHDHFVTFRLDLDIDGTENSFVRTELVTKRTP 496
            | .:|..:.:..|:|         ..:....|:..|         :.:|..|..|......|..|
Human   293 G-QKVGTLRFCGTTE---------FASGQWAGIELD---------EPEGKNNGSVGRVQYFKCAP 338

  Fly   497 KSVNTPRKSYWTTKRNTAKTEADARVKLGLRAEELVVVNPTK--KTKHGNEVGYRLLPG-----P 554
            |...|      |:|:.||             :|..:.:.|::  ||...|:...   ||     .
Human   339 KYGLT------TSKKETA-------------SESTLTLPPSEEPKTVAENDAAQ---PGSMSSSS 381

  Fly   555 ASSPLLVQDDYPQ 567
            :||.|..:..||:
Human   382 SSSSLDHKQSYPK 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	49/261 (19%)
MERTK	NP_006334.2	Ig	111..176	CDD:409353	8/50 (16%)
		Ig strand B	111..115	CDD:409353
		Ig strand C	127..131	CDD:409353
		Ig strand E	158..162	CDD:409353	2/3 (67%)
		Ig strand F	172..176	CDD:409353	0/3 (0%)
		IgI_2_Axl_Tyro3_like	198..279	CDD:409407	15/84 (18%)
		Ig strand A	198..201	CDD:409407	1/2 (50%)
		Ig strand A'	204..208	CDD:409407	0/3 (0%)
		Ig strand B	212..221	CDD:409407	3/8 (38%)
		Ig strand C	226..233	CDD:409407	1/6 (17%)
		Ig strand C'	235..238	CDD:409407	0/2 (0%)
		Ig strand E	243..254	CDD:409407	3/14 (21%)
		Ig strand F	257..266	CDD:409407	1/8 (13%)
		Ig strand G	270..279	CDD:409407	2/8 (25%)
		FN3	284..378	CDD:238020	27/134 (20%)
		FN3	386..478	CDD:238020	3/9 (33%)
		PTKc_Mer	579..862	CDD:271106