Protein Alignment drl and LOC100496572

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_001415012.1
• Gene: LOC100496572 / 100496572
• XenbaseID: XB-GENE-29083231
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 754
• Identity: 187/754 - (24%)
• Similarity: 303/754 - (40%)
• Gaps: 223/754 - (29%)

  Fly    10 LLLTLIASG----QAHLNIFLNLHEVLRLIGVSAELYYVREGAINDYALNFAVPVPANISD---- 66
            |:.||...|    .:..:|.|.:.|  .|.|..   ||:: |.|:....||..|...:|..
 Frog   612 LVCTLQTEGLPDTASTADIALTIDE--NLTGTP---YYIK-GTISAAGFNFVEPAITSIEPNFGP 670

  Fly    67 ------VTFTWQSLVDHPLPYSINIATSDTE-----------------------VLPRPI----L 98
                  :|...|           |:.:.:|:                       |.||.:    |
 Frog   671 LAGGTMLTLKGQ-----------NLRSGETQRVFISGAECMISGSLCPAEVLCCVSPRSLSLGPL 724

  Fly    99 NISRIGD-----------VPVEPQTWGIALKC---SGTR------NAEVTVTINVEVILDRATNN 143
            |:|.:.|           ...:|....|...|   ||||      |.:...:|.:.....:..::
 Frog   725 NVSALLDGAEISSPAQFQYKPDPLVSVIRPNCSLASGTRLTIQGSNLDSVSSIKISYSGQKTVSS 789

  Fly   144 NTNLIFKRKKICLREEQ--------------DSAHEEY-----------------DDDDLDLLQT 177
            :....|...:|..|..:              |:.:..|                 .|.|..:|:
 Frog   790 DCQGTFSSDRIVCRSPEYPYFGRPGNLTLALDAVNYIYPYRFRYLQNYVIHPFRPKDPDGGILK- 853

  Fly   178 ARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSKRDFDPMLREN------- 235
            .:||          .||   ...||  |....|.|...|.....|   |:.:|.:.:|
 Frog   854 LKKG----------EDE---IETHQ--ENLEQVATCLKVSMTVGG---RECNPTVLKNEITCRIP 900

  Fly   236 --LVPPASGLVT-------------------------LIVGGILALVLVSTLILIAYCAKGPSKR 273
              :|.|:.|.:.                         :::|.:.::::|:.||.:....:...|:
 Frog   901 KGMVIPSEGSIVQVCVDDDCTTVGLVMIVNMLDPVLGIVLGSVASVLVVAVLIFLLLKHQRKKKK 965

  Fly   274 HP--------SNG-----------VHLIKTSSFQRLPTISS---TAHNSIY--------VCPSTI 308
            .|        ||.           :|:...:|:  :|:.:|   .:|.:.|        ..|..:
 Frog   966 KPAVEALELLSNNNREPVLSPISLLHVDYRTSY--IPSSNSGGMLSHGAGYSGGSLGGGSMPILL 1028

  Fly   309 TPTYATLTRPFREYEHEPEEFNRRLQELTVQKC----RVRLSCLVQEGNFGRIYRGTY--NDCQE 367
            |....:|         .||........|..::|    |.|   ::.:|:||.:|.|||  .|.||
 Frog  1029 TSLLDSL---------RPELLEEVKDVLIPERCLTTHRDR---IIGKGHFGSVYHGTYVDEDQQE 1081

  Fly   368 V--LVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL--YAATGSVRNLK 428
            |  .||::.:.....:|...|:|.:::....||||||::||.:.....|.|:  :...|.:|:
 Frog  1082 VHCAVKSLNRITDLEEVEEFLREGILMKSFHHPNVLSLIGIFLPQEGLPLVVLPFMKHGDLRH-- 1144

  Fly   429 SFLQDPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDL 493
             |::  ...|:.|....|..|.|::..||:|.|...:|:|:|||||::|:...||:.|..|:||:
 Frog  1145 -FIR--CQERNPTVKDLVGFGLQVSRGMEYLANRKFVHRDLAARNCMLDETFHVKVADFGLARDV 1206

  Fly   494 FPGDYNSL--GDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEH 556
            |..:|.|:  ......|:||::||:||...:...|||||||||:||:.|.|..||.::|||::..
 Frog  1207 FDKEYYSVRRHKNARLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDPYDITR 1271

  Fly   557 YLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQL 595
            ||..|.|||||..|||.|:::|..||...|.|||:|:||
 Frog  1272 YLFRGRRLAQPEYCPDPLYSLMLSCWNPQPEERPTFTQL 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	35/192 (18%)
		PTK_Ryk	336..606	CDD:270639	106/272 (39%)
LOC100496572	NP_001415012.1	None