DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and erbb4

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	XP_031748752.1	Gene:	erbb4 / 100493234	XenbaseID:	XB-GENE-877077	Length:	1300	Species:	Xenopus tropicalis

Alignment Length:	440	Identity:	104/440 - (23%)
Similarity:	173/440 - (39%)	Gaps:	108/440 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 PMLRE--NLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPT 292
            |.|::  .::.....:...::||:..:|:::....:....|...|:....  ..::|...:.|
Frog   629 PRLKDCIGIIDRTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALR--RFLETELVEPL-- 689

  Fly   293 ISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRI 357
                       .||...|..|.|               |.|:|..:::.::     :..|.||.:
Frog   690 -----------TPSGTAPNQAQL---------------RILKETELKRIKI-----LGSGAFGTV 723

  Fly   358 YRGTYNDCQE-----VLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL 417
            |:|.:....|     |.:|.:.:..........:.|::::....||:::.:||:|:.
Frog   724 YKGIWVPEGETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLS-------- 780

  Fly   418 YAATGSVRNLKSFLQDPSYARSVTTIQTVL------------------MGSQL--------AMAM 456
                                   .|||.|.                  :||||        |..|
Frog   781 -----------------------PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGM 822

  Fly   457 EHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGD---YNSLGDGEYRPIKWLSLEALQ 518
            .:|....::|:|:||||.::.....||:||..|:| |..||   ||:  ||...||||::||.:.
Frog   823 MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLAR-LLEGDEKEYNA--DGGKMPIKWMALECIH 884

  Fly   519 KSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWA 583
            ...:...|||||:||.:||:.|.|..||..|...|:...|:.|.||.||..|..:::.:|..||.
Frog   885 YRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWM 949

  Fly   584 SMPAERPSFSQLQICLSEFHTQITRYVXPAVLKHAKTCKYNKRRRRKIFQ 633
            .....||.|.:|....|.......||:   |::.....|.......|.||
Frog   950 IDADSRPKFKELAAEFSRMARDPQRYL---VIQGDDRMKLPSPNDSKFFQ 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	80/303 (26%)
		Pkinase_Tyr	343..599	CDD:285015	79/289 (27%)
erbb4	XP_031748752.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910