DRSC/TRiP Functional Genomics Resources

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Protein Alignment drl and erbb2

DIOPT Version :10

Sequence 1:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster
Sequence 2:XP_002940420.3 Gene:erbb2 / 100492078 XenbaseID:XB-GENE-5938588 Length:1323 Species:Xenopus tropicalis


Alignment Length:654 Identity:156/654 - (23%)
Similarity:249/654 - (38%) Gaps:155/654 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 LNIFLNLHEVL-RLIGVSAELYYVREGAINDYALNFAVPVPANI------SDVTF----TWQSLV 75
            ||:|.||..:. |::...|....:|..:|:...|.....|.:.:      .|:.|    .|.||.
 Frog   422 LNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLF 486

  Fly    76 DHPLPYSINIATSDTEVLPRPILN-ISRI-GDVPVEPQTWG----IALKCSG-TRNAEVTVTINV 133
            .:|....:.......|...:...| .||. |:     :.||    ..::|:| .|..:...:.||
 Frog   487 RNPRQTILKTINKPQEACDQEGQNCFSRCDGN-----KCWGPGPSQCVRCNGFLRGHDCIESCNV 546

  Fly   134 EVILDRATNNNTNLIFKRKKICLRE------EQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRN 192
            .....|...|.:..:....: ||.:      ....||:        .::.|        ||:|..
 Frog   547 LDGYPREHVNGSQCVPCHPQ-CLPQNGTLTCNGTEAHQ--------CMECA--------HYLDGE 594

  Fly   193 DEHVVANGHQAPEKQRPVVTESPVG-RGNS---------------------GGSKRDFD----PM 231
            |                .|.:.|.| :|||                     ..|....|    |:
 Frog   595 D----------------CVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNCSHSCNQLDERGCPI 643

  Fly   232 LRENLVPPASGLVTLIVGGILALVLVST-LILIAYCAKGPSKRHPSNGVHLIKTSSFQRLPTISS 295
            |.:|   ....:|..||..||.::.:|| ::|.....|...|:|...  .|::....:.|     
 Frog   644 LPDN---SQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMR--RLLQDELVEPL----- 698

  Fly   296 TAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRG 360
                    .||...|..|.:               |.|:|..::|..:     :..|.||.:|:|
 Frog   699 --------TPSGAIPNQAQM---------------RILKETELKKMMI-----LGSGAFGTVYKG 735

  Fly   361 TY-----NDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHPNVLSVLGI---SIEDYATPFVL 417
            .:     |....|.:|.:.::.|......:|.|:.::.....|.|..:|||   |.....|..:.
 Frog   736 IWIPDGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQLVTQLMP 800

  Fly   418 YAATGSVRNLKSFLQDPSYARS----VTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDD 478
            |..          |.|  |.|.    :.:...:....|:|..|.:|.:..::|:|:||||.::..
 Frog   801 YGC----------LLD--YVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKS 853

  Fly   479 QLRVKLTDSALSR--DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTL 541
            ...||:||..|:|  |:...:|::  ||...||||::||::....:...|||||:||.:||:.|.
 Frog   854 PSHVKITDFGLARLLDVDETEYHA--DGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTF 916

  Fly   542 GKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEFHTQI 606
            |..||..|...|:...|:.|.||.||..|..:::.||..||......||.|..|...||......
 Frog   917 GAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDP 981

  Fly   607 TRYV 610
            :|||
 Frog   982 SRYV 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drlNP_001260566.1 WIF 21..157 CDD:128745 32/152 (21%)
PTK_Ryk 336..606 CDD:270639 82/283 (29%)
erbb2XP_002940420.3 Recep_L_domain 56..168 CDD:460032
Furin-like 184..340 CDD:395614
Recep_L_domain 366..479 CDD:460032 13/56 (23%)
GF_recep_IV 511..642 CDD:464344 29/168 (17%)
PTKc_HER2 710..988 CDD:270684 88/310 (28%)
COG4372 <1153..>1317 CDD:443500
CwlO1 <1161..>1232 CDD:443091
Blue background indicates that the domain is not in the aligned region.

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