Protein Alignment drl and epha4

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_012825631.1
• Gene: epha4 / 100216124
• XenbaseID: XB-GENE-1015803
• Length: 986
• Species: Xenopus tropicalis
• Alignment Length: 530
• Identity: 124/530 - (23%)
• Similarity: 225/530 - (42%)
• Gaps: 112/530 - (21%)

  Fly   111 QTW---GIALKCSGTRNA-EVTVTIN-------VEVILDRATNNNTNLIF----KRKKICLREEQ 160
            :.|   |::.:..|...| .||||.|       .::.....|.::.:|.:    :...:.|..|.
 Frog   411 EVWAINGVSKQNPGQDQAVSVTVTTNQAAPSTVTQIQPKEITRHSVSLTWPEPERANGVILEYEV 475

  Fly   161 DSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGNSGGSK 225
            ....::.::....:::||.:  ..||..::....:|.   |        |...:..|.|...|
 Frog   476 KYYEKDQNERSYRIVKTASR--SADIKGLNPLTAYVF---H--------VRARTAAGYGEFSG-- 525

  Fly   226 RDFD--------PMLRENLVPPASGLVTLIVGGI-LALVLVSTLILIAYCAK-GPSKRHPSNGVH 280
             .|:        ||:.|...|..  |:..:.|.| |.::|::..::....:| ..:|:......|
 Frog   526 -PFEFTTNTVPSPMIGEGASPTV--LLVSVAGSIVLVVILIAAFVISRRRSKYSKAKQEADEEKH 587

  Fly   281 L---IKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCR 342
            |   :||                 ||.|.    ||....:..||:..|            :....
 Frog   588 LNQGVKT-----------------YVDPF----TYEDPNQAVREFAKE------------IDASC 619

  Fly   343 VRLSCLVQEGNFGRIYRG---------TYNDCQEVLVKTVAQHASQLQVNLLLQESMMLYEASHP 398
            :::..::..|.||.:..|         .|     |.:||:....:..|....|.|:.::.:..||
 Frog   620 IKIEKVIGVGEFGEVCSGRLKVPGKREIY-----VAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 679

  Fly   399 NVLSVLGISIEDYATPFVL---YAATGSVRNLKSFLQ--DPSYARSVTTIQTVLMGSQLAMAMEH 458
            |::.:.|:..:  ..|.::   |...||   |.:||:  |..:    |.||.|.|...:...|::
 Frog   680 NIIHLEGVVTK--CKPVMIITEYMENGS---LDAFLRKNDGRF----TVIQLVGMLRGIGSGMKY 735

  Fly   459 LHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR---DLFPGDYNSLGDGEYRPIKWLSLEALQKS 520
            |.:...:|:|:||||.:::..|..|::|..:||   |.....|.:.| |:. ||:|.:.||:...
 Frog   736 LSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG-GKI-PIRWTAPEAIAYR 798

  Fly   521 HYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASM 585
            .:...|||||:|::|||:.:.|:.||.::...::...:::||||..|.:||..|..:|..||...
 Frog   799 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKE 863

  Fly   586 PAERPSFSQL 595
            .::||.|.|:
 Frog   864 RSDRPKFGQI 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	11/60 (18%)
		PTK_Ryk	336..606	CDD:270639	77/277 (28%)
epha4	XP_012825631.1	EphR_LBD_A4	30..203	CDD:198450
		FN3	329..435	CDD:238020	7/23 (30%)
		FN3	440..531	CDD:238020	15/106 (14%)
		EphA2_TM	550..617	CDD:464211	18/99 (18%)
		PTKc_EphR_A	615..881	CDD:270651	77/275 (28%)
		SAM_EPH-A4	911..981	CDD:188944