Protein Alignment drl and fgfr3

DIOPT Version :10

• Sequence 1: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: XP_012812743.1
• Gene: fgfr3 / 100196923
• XenbaseID: XB-GENE-479255
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 597
• Identity: 160/597 - (26%)
• Similarity: 248/597 - (41%)
• Gaps: 154/597 - (25%)

  Fly   102 RIGDVPVEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQ-DSAHE 165
            |||.:.:..|.|.:.:                |.::.....|.|         |:.|.: .|..:
 Frog   216 RIGGIKLRHQQWSLVM----------------ESVVPSDKGNYT---------CVVENKYGSIRQ 255

  Fly   166 EYDDDDLDLLQTARKGH----------------GGDIH-----YVDRND-----EHVVANGHQ-A 203
            .|   .||:|:  |..|                |.|:.     |.|...     :||..||.: .
 Frog   256 TY---QLDVLE--RSSHRPILQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKYG 315

  Fly   204 PEKQRPV--------------------VTESPVG----RGNS--GGSKRDF----------DPML 232
            |:....|                    |||:..|    |.|:  |.::..|          :|:.
 Frog   316 PDGDPYVTVLQSFTNGTEVDTTLSLKNVTETHEGQYVCRANNFIGVAEASFWLHIYKPASAEPVE 380

  Fly   233 RENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPS-NGVHLIKTSSF----QRLPT 292
            :......:|..|.::|..|...:|: .:|.:.|..|.|||:..| ..||  |.|.|    |::..
 Frog   381 KPTTTSSSSTTVLIVVSVITGFILL-VIIFVTYRVKVPSKKAMSAPPVH--KVSKFPLKRQQVSL 442

  Fly   293 ISSTAHNS---------IYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLSCL 348
            .|:::.||         :.....|:....:.|..|.     :|:      .||.  :.|:.|...
 Frog   443 ESNSSMNSNTPLVRITHLSSSDGTMLANVSELGLPL-----DPK------WELL--RTRLTLGKP 494

  Fly   349 VQEGNFGR--------IYRGTYNDCQEVLVKTVAQHASQLQVNLLLQE-SMMLYEASHPNVLSVL 404
            :.||.||:        |.:...|....|.||.:...|:...::.|:.| .||.....|.|::::|
 Frog   495 LGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLL 559

  Fly   405 GISIED---YATPFVLYAATGSVRNLKSFLQ-------DPSY------ARSVTTIQTVLMGSQLA 453
            |...:|   |.  .|.||:.|   ||:.:|:       |.|:      |..:|....|....|:|
 Frog   560 GACTQDGPLYV--LVEYASKG---NLREYLKARRPPGMDYSFDTCKIPAEQLTFKDLVSCAYQVA 619

  Fly   454 MAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQ 518
            ..||:|.:...||:|:||||.::.|...:|:.|..|:||:...||.........|:||::.|||.
 Frog   620 RGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNIDYYKKTTNGRLPVKWMAPEALF 684

  Fly   519 KSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWA 583
            ...|...|||||:|||:||..|||..||..|...|:...||:|:|:.:|.||..||:.||..||.
 Frog   685 DRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWH 749

  Fly   584 SMPAERPSFSQL 595
            ::|::||:|.||
 Frog   750 AVPSQRPTFKQL 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745	9/54 (17%)
		PTK_Ryk	336..606	CDD:270639	98/285 (34%)
fgfr3	XP_012812743.1	Ig	<75..128	CDD:472250
		Ig strand B	78..82	CDD:409353
		Ig strand C	90..94	CDD:409353
		Ig strand E	111..115	CDD:409353
		IgI_2_FGFR	167..261	CDD:409443	13/72 (18%)
		Ig strand A	167..170	CDD:409443
		Ig strand A'	178..183	CDD:409443
		Ig strand B	187..195	CDD:409443
		Ig strand C	201..206	CDD:409443
		Ig strand C'	209..211	CDD:409443
		Ig strand D	220..223	CDD:409443	0/2 (0%)
		Ig strand E	227..232	CDD:409443	1/20 (5%)
		Ig strand F	241..248	CDD:409443	3/15 (20%)
		Ig strand G	251..261	CDD:409443	3/12 (25%)
		IgI_3_FGFR	269..369	CDD:409363	18/99 (18%)
		Ig strand A	269..272	CDD:409363	0/2 (0%)
		Ig strand A'	276..280	CDD:409363	0/3 (0%)
		Ig strand B	288..295	CDD:409363	0/6 (0%)
		Ig strand C	299..306	CDD:409363	0/6 (0%)
		Ig strand D	321..326	CDD:409363	1/4 (25%)
		Ig strand E	336..341	CDD:409363	0/4 (0%)
		Ig strand F	349..357	CDD:409363	2/7 (29%)
		Ig strand G	360..368	CDD:409363	2/7 (29%)
		PTKc_FGFR3	476..809	CDD:173652	101/304 (33%)