DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drl and erbb4a

DIOPT Version :9

Sequence 1:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_001137223.1	Gene:	erbb4a / 100007677	ZFINID:	ZDB-GENE-030918-4	Length:	1414	Species:	Danio rerio

Alignment Length:	409	Identity:	102/409 - (24%)
Similarity:	173/409 - (42%)	Gaps:	72/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RGNSGGSKRDFDPML-RENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVHL 281
            :|.:|...:|...|| |..|:  |:||    :||:..:|:::..:.:....|...|:....  ..
Zfish   622 QGCTGPRIQDCVGMLDRTPLI--AAGL----IGGLFVIVIIALSVAVYIRRKSIKKKRALR--RF 678

  Fly   282 IKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRLS 346
            ::|...:.|             .||...|..|.|               |.|:|..:::.::
Zfish   679 LETELVEPL-------------TPSGAAPNQAQL---------------RILKETELKRVKI--- 712

  Fly   347 CLVQEGNFGRIYRGTYNDCQEVLVKTVA----QHASQLQVNL-LLQESMMLYEASHPNVLSVLGI 406
              :..|.||.:| |.:....|.:...||    ..::..:.|: .:.|::::....||:::.:||:
Zfish   713 --LGAGAFGMVYXGIWVPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGV 775

  Fly   407 SIEDYATPFVLYAATGSVRNLKSFLQDPSYARSVTTIQTVLMGSQL--------AMAMEHLHNHG 463
            .:.............|.:.:.....||.             :||||        |..|. |....
Zfish   776 CLSPTIQLVTQLMPHGCLLDYVHEHQDN-------------IGSQLLLNWCVQIAKGMMXLEERR 827

  Fly   464 VIHKDIAARNCVIDDQLRVKLTDSALSR--DLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEGS 526
            ::|: :||||.::.....:|:||..|:|  |....:|||  ||...||||::||.:....:...|
Zfish   828 LVHRXLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNS--DGGKMPIKWMALECIHYRKFTHQS 890

  Fly   527 DVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPS 591
            ||||:||.:||:.|.|. ||..|...::...|:.|.||.||..|..:::.:|..||......||.
Zfish   891 DVWSYGVTIWELMTFGGXPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPR 955

  Fly   592 FSQLQICLSEFHTQITRYV 610
            |.:|....|.......||:
Zfish   956 FKELAAEFSRMARDPQRYL 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	75/284 (26%)
		Pkinase_Tyr	343..599	CDD:285015	74/270 (27%)
erbb4a	NP_001137223.1	Recep_L_domain	54..166	CDD:279382
		FU	182..216	CDD:214589
		Furin-like	184..331	CDD:279142
		FU	228..273	CDD:238021
		Recep_L_domain	357..477	CDD:279382
		GF_recep_IV	501..632	CDD:291509	2/9 (22%)
		FU	502..552	CDD:238021
		FU	548..595	CDD:214589
		TM_ErbB4	631..674	CDD:213053	13/48 (27%)
		PKc_like	699..995	CDD:304357	81/311 (26%)
		Pkinase_Tyr	707..963	CDD:285015	74/275 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900