DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Tec

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_445884.1	Gene:	Tec / 84492	RGDID:	620973	Length:	629	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	192/814 - (23%)
Similarity:	315/814 - (38%)	Gaps:	244/814 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 ILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGR---NIDNGYVPLHEAAK 230
            ||:.:|..:.|.....|    ||:|    |...|:.|. |.....:||   ....|::.:
  Rat     6 ILEEILIKRSQQKKKTS----PLNY----KERLFVLTK-SVLTYYEGRAEKKYRKGFIDI----- 56

  Fly   231 HGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTR 295
             ..::.| |::..:...:|  ...:|||.:..:|...        |...|:..:||:|.
  Rat    57 -SKIKCV-EIVKNDDGIIP--CQNKFPFQVVHDANTL--------YIFAPSPQSRDRWV------ 103

  Fly   296 EEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGN 360
                    |..||      |:..:...:::|.....|.|..  ..|.|.               .
  Rat   104 --------KKLKE------EIKNNNNIMIKYHPKFWADGSY--QCCRQT---------------E 137

  Fly   361 KVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPK 425
            |:..|..|:...:.                       |::..:||.|:        |.|
  Rat   138 KLAPGCEKYNLFES-----------------------SIRKTLPPAPE--------IKR------ 165

  Fly   426 AASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKS-- 488
                 .||.|:.|...:....|.|:       .:..::..:.|||...::.:.    |.||.:
  Rat   166 -----RPPPPIPPEEENTEEIVVAM-------YDFQATEAHDLRLERGQEYII----LEKNDTHW 214

  Fly   489 ------------------KGKRS-----------DSESSVSGSLAGTEQE------LQAAAPMLK 518
                              .||:|           ::..|.:..|..||.:      ..::.|.|.
  Rat   215 WRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLY 279

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERE 583
            ::|..|:|.        |.|::.....:......:|.:..|        ||...|......||..
  Rat   280 TVSLYTKFG--------GEGSSGFRHYHIKETATSPKKYYL--------AEKHAFGSIPEIIEYH 328

  Fly   584 R---AGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSA 645
            :   ||                |..:::.|    :::.|.||.|   .|.:.:.|
  Rat   329 KHNAAG----------------LVTRLRYP----VSTKGKNAPT---TAGFSYDK---------- 360

  Fly   646 TEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQE 709
                     :.|.|.:|...||:|.|.||.|..| |         .::.:||||.:.:....:::
  Rat   361 ---------WEINPSELTFMRELGSGLFGVVRLGKW---------RAQYKVAIKAIREGAMCEED 407

  Fly   710 FLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILD-HGHEITANAELKVWASQ 772
            |:.||.|||:|.|..:|:|.|: .:.:.:.:|.|....|.:|.::.. .||   .:.::.:...|
  Rat   408 FIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH---FSRDVLLSMCQ 469

  Fly   773 IAC-GMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAP 836
            ..| ||.|||...|:||||||||.|:......|:|||||:|.:.  ..:|..:.|.::|::|..|
  Rat   470 DVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVL--DDQYTSSSGAKFPVKWCPP 532

  Fly   837 ESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQ 901
            |.||...||..||||||||.:||:|:.|..|:.:.:|.:.:.:|..|.|||:|.|...|:|.||.
  Rat   533 EVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVML 597

  Fly   902 SCWKERPKDRPTFVYLTEFFARDPDYQNLPELVQ 935
            .||:|||:.||:|..|         .:.:.|||:
  Rat   598 RCWQERPEGRPSFEDL---------LRTIDELVE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	4/14 (29%)
		ANK	117..241	CDD:238125	17/74 (23%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786	4/14 (29%)
		Ank_2	158..247	CDD:289560	17/80 (21%)
		ANK repeat	186..217	CDD:293786	9/33 (27%)
		ANK repeat	220..245	CDD:293786	3/24 (13%)
		Ank_4	224..274	CDD:290365	7/49 (14%)
		SH2_Cterm_shark_like	287..395	CDD:198211	13/107 (12%)
		TyrKc	662..921	CDD:197581	99/262 (38%)
		PTKc_Syk_like	666..926	CDD:270650	98/263 (37%)
Tec	NP_445884.1	PH_Btk	7..148	CDD:269944	38/203 (19%)
		SH3_Tec	181..235	CDD:212838	8/64 (13%)
		SH2_Tec_Itk	238..345	CDD:198259	22/142 (15%)
		PTKc_Tec_Rlk	363..622	CDD:270685	103/281 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810