DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shark and HT1

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_176430.2	Gene:	HT1 / 842538	AraportID:	AT1G62400	Length:	390	Species:	Arabidopsis thaliana

Alignment Length:	314	Identity:	85/314 - (27%)
Similarity:	138/314 - (43%)	Gaps:	48/314 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 PSTPSAT------EVEAAKLRFF--IEPEKLVLDR------EIGHGEFGSVHSGW--------LL 682
            |..||::      |.|..:.:.|  :|...::|:.      |...||    ...|        :.
plant    29 PCNPSSSKTNRYAEAETMEKKRFDSMESWSMILESENVETWEASKGE----REEWTADLSQLFIG 89

  Fly   683 RKSGAGEESRL--------EVAIKML-----SDEHSNK--QEFLREASVMMRLEHKCIVRLIGIA 732
            .|..:|..||:        .||:||:     .:|...|  |:|..|.:::.||.|..||:.|...
plant    90 NKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAAC 154

  Fly   733 -KGEMLMMVQELAPLGSMLQYI-LDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNI 795
             |..:..::.|....|::..|: ....:.::....|:: |..|:.||.||.||..:||||.:.|:
plant   155 KKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRL-ALDISRGMEYLHSQGVIHRDLKSNNL 218

  Fly   796 LLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEM 860
            ||....:.|::|||.|..    .|:.:..:|.....||.|||......::...||:|||:.:||:
plant   219 LLNDEMRVKVADFGTSCL----ETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWEL 279

  Fly   861 FSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .:...|..|......|..:.:..||.|.|..|...:..:::.||.|.|..||.|
plant   280 TTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDF 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	78/284 (27%)
		PTKc_Syk_like	666..926	CDD:270650	77/280 (28%)
HT1	NP_176430.2	STKc_MAP3K-like	93..340	CDD:270901	72/246 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1725
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050