DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and YES1

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_005424.1 Gene:YES1 / 7525 HGNCID:12841 Length:543 Species:Homo sapiens


Alignment Length:546 Identity:143/546 - (26%)
Similarity:232/546 - (42%) Gaps:115/546 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 RKNKS---KGKRSDSESSVSGSLA--GTEQELQAAAPMLKSLSFSTEFSTFN------ADGVTGS 537
            ::|||   |.:..::...||.|::  |.|....:..|...:...:..||:.:      :.|||..
Human     7 KENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPF 71

  Fly   538 GAAAAGEVYNVPRNNTP--------IEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQW------ 588
            |.|::.  ::|..::.|        |.:.|.....:|..::.:.......|.....|.|      
Human    72 GGASSS--FSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSI 134

  Fly   589 -IG-NGYQPTMDV------------------------------------------------LSLL 603
             .| |||.|:..|                                                ||:.
Human   135 ATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIR 199

  Fly   604 D------QQIKAPAVARLNSLGPNASTESEMAS--------------YLHRKCSGTPSTPSATEV 648
            |      ..:|...:.:|::.|...:|.::..:              ..|:..:..|:....|: 
Human   200 DWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQ- 263

  Fly   649 EAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLR 712
            ..||..:.|..|.|.|:.::|.|.||.|..| |         ....:||||.|.......:.||:
Human   264 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW---------NGTTKVAIKTLKPGTMMPEAFLQ 319

  Fly   713 EASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGM 777
            ||.:|.:|.|..:|.|..:...|.:.:|.|....||:|.::.:...:.....:|...|:|||.||
Human   320 EAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGM 384

  Fly   778 HYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLG 842
            .|:|..:::||||.|.|||:......||:|||::|.:.  ..||...||.::||:|.|||:...|
Human   385 AYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYG 447

  Fly   843 IFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKER 907
            .|:..|||||||:...|:.:.|..||..:.|.:.::.|:.|.|:|.|..||..::.:|..|||:.
Human   448 RFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKD 512

  Fly   908 PKDRPTFVYLTEFF-----ARDPDYQ 928
            |.:||||.|:..|.     |.:|.||
Human   513 PDERPTFEYIQSFLEDYFTATEPQYQ 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 93/259 (36%)
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
YES1NP_005424.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45 10/37 (27%)
SH3_Yes 94..151 CDD:212940 12/56 (21%)
SH2_Src_family 154..253 CDD:199827 8/98 (8%)
PTKc_Yes 264..542 CDD:270654 102/286 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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