DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and SYK

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001167638.1	Gene:	SYK / 6850	HGNCID:	11491	Length:	635	Species:	Homo sapiens

Alignment Length:	935	Identity:	223/935 - (23%)
Similarity:	345/935 - (36%)	Gaps:	342/935 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRDSDPMKWYHGNLSREAADELLKQ-GYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH- 63
            |:..::.:.::.||::||.|::.|.| |..||.:|:|:|....|.|.||:....:..||.:.|.
Human     6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL 70

  Fly    64 -------GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVT 121
                   ||.......|             |..|:.|.::||...|..|.        .|..||.
Human    71 NGTYAIAGGRTHASPAD-------------LCHYHSQESDGLVCLLKKPF--------NRPQGVQ 114

  Fly   122 NLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSF 186
            .                  |.|                     ..||:.::|
Human   115 P------------------KTG---------------------PFEDLKENL------------- 127

  Fly   187 GCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRT 251
                            ||..:....|:||                   :|:::.::::.|
Human   128 ----------------IREYVKQTWNLQG-------------------QALEQAIISQKP----- 152

  Fly   252 SSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEV 316
                   .|.|....||.|      |:|        |:||.::|||:..|:...:|
Human   153 -------QLEKLIATTAHE------KMP--------WFHGKISREESEQIVLIGSK--------- 187

  Fly   317 DTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSV 381
             |:|.||:|..::..:  ..|.||.:..|.::||   |..:.|......|.||     ...|..|
Human   188 -TNGKFLIRARDNNGS--YALCLLHEGKVLHYRI---DKDKTGKLSIPEGKKF-----DTLWQLV 241

  Fly   382 EHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPH 446
            ||       :||.....|:
Human   242 EH-------YSYKADGLLR---------------------------------------------- 253

  Fly   447 VPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQ 511
              .||:..:|.....:..|                                       |...:|.
Human   254 --VLTVPCQKIGTQGNVNF---------------------------------------GGRPQLP 277

  Fly   512 AAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVP----RNNTPIEIDLPPIAQKTEAEVEY 572
            .:.|           :|::|.|:     .:..:.|:.|    |.::|.:      ..:.|:.|.:
Human   278 GSHP-----------ATWSAGGI-----ISRIKSYSFPKPGHRKSSPAQ------GNRQESTVSF 320

  Fly   573 FTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNAST---ESEMASYLHR 634
                              |.|:|.:           ||..|   ..||....   ::|:.
Human   321 ------------------NPYEPEL-----------APWAA---DKGPQREALPMDTEVY----- 348

  Fly   635 KCSGTPSTPSATEVEAAKLRFFIEPEKLVL-DREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIK 698
                  .:|.|...|......:::.:.|.| |:|:|.|.||:|..|:...|...     ..||:|
Human   349 ------ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVV-----KTVAVK 402

  Fly   699 MLSDEHSN---KQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEI 760
            :|.:|.::   |.|.|.||:||.:|::..|||:|||.:.|..|:|.|:|.||.:.:|:..:.|..
Human   403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK 467

  Fly   761 TAN-AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFT 824
            ..| .||   ..|::.||.|||..:||||||||||:||..:|.|||||||:|::||.....|:..
Human   468 DKNIIEL---VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 529

  Fly   825 QGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQP 889
            ..|:||::|||||..|...||..||||||||.:||.||.|..||..:...:...:::.|||:..|
Human   530 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594

  Fly   890 NLCPAYIYAVMQSCWKERPKDRPTF 914
            ..||..:|.:|..||....::||.|
Human   595 AGCPREMYDLMNLCWTYDVENRPGF 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	24/91 (26%)
		Ank_2	<112..184	CDD:289560	8/71 (11%)
		ANK	117..241	CDD:238125	13/123 (11%)
		ANK repeat	124..151	CDD:293786	2/26 (8%)
		ANK repeat	153..184	CDD:293786	3/30 (10%)
		Ank_2	158..247	CDD:289560	9/88 (10%)
		ANK repeat	186..217	CDD:293786	5/30 (17%)
		ANK repeat	220..245	CDD:293786	1/24 (4%)
		Ank_4	224..274	CDD:290365	7/49 (14%)
		SH2_Cterm_shark_like	287..395	CDD:198211	30/107 (28%)
		TyrKc	662..921	CDD:197581	111/258 (43%)
		PTKc_Syk_like	666..926	CDD:270650	108/253 (43%)
SYK	NP_001167638.1	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191	33/141 (23%)
		Interdomain A	108..167		21/163 (13%)
		SH2_C-SH2_Syk_like	164..262	CDD:198264	36/186 (19%)
		Interdomain B	260..370		26/213 (12%)
		PTKc_Syk	375..631	CDD:133247	108/253 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2843
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345546at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105357
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.830