DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and SRC

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_016883513.1 Gene:SRC / 6714 HGNCID:11283 Length:542 Species:Homo sapiens


Alignment Length:584 Identity:159/584 - (27%)
Similarity:248/584 - (42%) Gaps:121/584 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 PSFATIPRSNMKPK--------AASPA--TPPTPVSPHSHH--QHPHVPALTITKKKQKENSSSM 464
            |..|:..|.:::|.        .|.||  ||..|.|...|.  .....||....|.....|||. 
Human     8 PKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSD- 71

  Fly   465 FNTLRLTSPKK------------ALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPML 517
                .:|||::            ||:|..|..:.....|:.:....|:                 
Human    72 ----TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN----------------- 115

  Fly   518 KSLSFSTEFSTFNADGVTG----SGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDV 578
                     :|...|...|    :.:.:.|:...:|.|.      :.| :...:||..||.|   
Human   116 ---------NTRKVDVREGDWWLAHSLSTGQTGYIPSNY------VAP-SDSIQAEEWYFGK--- 161

  Fly   579 AIERERAGQWIGNGYQP--TMDV-----------LSLLD------QQIKAPAVARLNSLGPNAST 624
             |.|..:.:.:.|...|  |..|           ||:.|      ..:|...:.:|:|.|...::
Human   162 -ITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITS 225

  Fly   625 ESEMAS--------------YLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGS 675
            .::..|              ..||..:..|::...|: ..||..:.|..|.|.|:.::|.|.||.
Human   226 RTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQ-GLAKDAWEIPRESLRLEVKLGQGCFGE 289

  Fly   676 VHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMM 739
            |..| |         .....||||.|.....:.:.||:||.||.:|.|:.:|:|..:...|.:.:
Human   290 VWMGTW---------NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI 345

  Fly   740 VQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAK 804
            |.|....||:|.::.....:.....:|...|:|||.||.|:|..::|||||.|.|||:......|
Human   346 VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCK 410

  Fly   805 ISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYG 869
            ::|||::|.:.  ..||...||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||.
Human   411 VADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 473

  Fly   870 EISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            .:.|.:.:..|:.|.|:|.|..||..::.:|..||::.|::||||.||..|.     :.:|.||
Human   474 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 94/259 (36%)
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
SRCXP_016883513.1 SH3_Src 88..149 CDD:212941 13/93 (14%)
SH2_Src_Src 153..253 CDD:198228 21/103 (20%)
PTKc_Src 266..542 CDD:270656 101/283 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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