DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and BMX

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001712.1	Gene:	BMX / 660	HGNCID:	1079	Length:	675	Species:	Homo sapiens

Alignment Length:	810	Identity:	196/810 - (24%)
Similarity:	316/810 - (39%)	Gaps:	210/810 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKH 231
            :.||:.||..:.|.....|    |.:|    |...|:.|    :.|:.....|.    :...::.
Human     4 KSILEELLLKRSQQKKKMS----PNNY----KERLFVLT----KTNLSYYEYDK----MKRGSRK 52

  Fly   232 GNLE-----AVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHG 291
            |::|     .|:::.|.|..|:.|    ::||.:..:.|        |.|.......:|.||
Human    53 GSIEIKKIRCVEKVNLEEQTPVER----QYPFQIVYKDG--------LLYVYASNEESRSQW--- 102

  Fly   292 TLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLY 356
                             |.|.|.|:..:...||:|.......|   ..||              .
Human   103 -----------------LKALQKEIRGNPHLLVKYHSGFFVDG---KFLC--------------C 133

  Fly   357 QNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSF----ATI 417
            |...|...|.:         .|.:..:|                :....:.|..||:|    ..|
Human   134 QQSCKAAPGCT---------LWEAYANL----------------HTAVNEEKHRVPTFPDRVLKI 173

  Fly   418 PRS--NMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSM-------FNTLRLTSP 473
            ||:  .:|..|.|.:|........|...:...|..:.|...|.:::|..       ||...:  |
Human   174 PRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYI--P 236

  Fly   474 KKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSG 538
            ::...|...:||.||        ||.|..:|.:.|:.:
Human   237 REDFPDWWQVRKLKS--------SSSSEDVASSNQKER--------------------------- 266

  Fly   539 AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAE----VEYFTKSDVAIERERAGQ-----------W 588
                    ||....:.|..:.|..:...|.|    .::|..:   |.|.::.|           .
Human   267 --------NVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN---ISRSQSEQLLRQKGKEGAFM 320

  Fly   589 IGNGYQPTMDVLSLLDQQI--KAPAVARLNSLGPNASTESEMAS------------YLHRKCSGT 639
            :.|..|..|..:||..:.:  |...|...: :..||..:..:|.            |.....:|.
Human   321 VRNSSQVGMYTVSLFSKAVNDKKGTVKHYH-VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGM 384

  Fly   640 ------PSTPSATEV-EAAKLR---FFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRL 693
                  |.:..|.:| ::..|.   :.::.|::.|.:|:|.|:||.|..| |         :.:.
Human   385 ITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKW---------KGQY 440

  Fly   694 EVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEM-LMMVQELAPLGSMLQYILDHG 757
            :||:||:.:...::.||.:||..||:|.|..:|:..|:...|. :.:|.|....|.:|.|:..||
Human   441 DVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG 505

  Fly   758 HEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQ 822
            ..:..:..|:: ...:..||.:|||..|:||||||||.|:......|:|||||:|.:.  ..:|.
Human   506 KGLEPSQLLEM-CYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVL--DDQYV 567

  Fly   823 FTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLP 887
            .:.|.::|::|.|||.|:...:|..||||:||:.:||:||||..||....|...:..|..|.||.
Human   568 SSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLY 632

  Fly   888 QPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917
            :|:|....||.:|.|||.|.|:.||||..|
Human   633 RPHLASDTIYQIMYSCWHELPEKRPTFQQL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	5/16 (31%)
		ANK	117..241	CDD:238125	16/78 (21%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786	5/16 (31%)
		Ank_2	158..247	CDD:289560	18/84 (21%)
		ANK repeat	186..217	CDD:293786	6/30 (20%)
		ANK repeat	220..245	CDD:293786	4/29 (14%)
		Ank_4	224..274	CDD:290365	10/54 (19%)
		SH2_Cterm_shark_like	287..395	CDD:198211	17/107 (16%)
		TyrKc	662..921	CDD:197581	97/258 (38%)
		PTKc_Syk_like	666..926	CDD:270650	96/254 (38%)
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944	40/213 (19%)
		SH2_Tec_Bmx	289..394	CDD:198262	18/108 (17%)
		PTKc_Btk_Bmx	412..667	CDD:173657	98/263 (37%)
		CAV1-binding	596..603		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910