DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and BLK

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_011542126.1 Gene:BLK / 640 HGNCID:1057 Length:531 Species:Homo sapiens


Alignment Length:621 Identity:162/621 - (26%)
Similarity:251/621 - (40%) Gaps:179/621 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 VSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENS 461
            ||.|.|...:|..|.......|   :|..|.....||.|.....:|..|..|...:.:.|.    
Human     4 VSSKKPDKEKPIKEKDKGQWSP---LKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKH---- 61

  Fly   462 SSMFNTLRLTSPKKALFD---MNSLRKNKSKGKRSD----------SESSVSG------------ 501
               |..        ||:|   ||.......||::..          :.|.|:|            
Human    62 ---FVV--------ALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVAR 115

  Fly   502 ------------SLAGTEQELQAAAPMLKSLSFSTEFSTFN-------ADGVTGSG--------- 538
                        |....|.|.|..||:.|:.||....|..|       ...||..|         
Human   116 VESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180

  Fly   539 AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLL 603
            ....|..|..||      |..|.:    :|.|::::|.             |:|          |
Human   181 CLDEGGYYISPR------ITFPSL----QALVQHYSKK-------------GDG----------L 212

  Fly   604 DQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREI 668
            .|::..|.|                        ...|..|.|.:      .:.|..:.|.|.|::
Human   213 CQRLTLPCV------------------------RPAPQNPWAQD------EWEIPRQSLRLVRKL 247

  Fly   669 GHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAK 733
            |.|:||.|..|:.        ::.::||||.|.:...:.:.||.||:||..|:|:.:|||..:..
Human   248 GSGQFGEVWMGYY--------KNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVT 304

  Fly   734 GEMLMMVQEL-----AP---------------------LGSMLQYI-LDHGHEITANAELKVWAS 771
            .|.:.:|.|.     ||                     .|.:|.:: .|.|..::. ..|...::
Human   305 KEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRLSL-PRLIDMSA 368

  Fly   772 QIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAP 836
            |||.||.|:|..:.:||||.|.|||::.....||:|||::|.:   .:||...:|.::||:|.||
Human   369 QIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII---DSEYTAQEGAKFPIKWTAP 430

  Fly   837 ESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIY-AVM 900
            |:.:.|:|:..:|||||||.:.|:.:.|..||..:||.:.|:.::.|.|:|:|:.||..:| .|:
Human   431 EAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVI 495

  Fly   901 QSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            ..||:.||::||||.:    |.:|: |.:..|:..|
Human   496 AECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 98/290 (34%)
PTKc_Syk_like 666..926 CDD:270650 98/292 (34%)
BLKXP_011542126.1 SH3_Blk 62..115 CDD:212942 11/60 (18%)
SH2_Src_Blk 120..219 CDD:198234 27/131 (21%)
PKc_like 233..522 CDD:304357 100/300 (33%)
Pkinase_Tyr 241..516 CDD:285015 97/286 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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