DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and PTK6

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens

Alignment Length:	425	Identity:	138/425 - (32%)
Similarity:	209/425 - (49%)	Gaps:	63/425 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 GAAAAGEVYNVPRNNTPIEIDLPPIAQK--TEAEVEYF---TKSDVAIERERAGQWIGN-----G 592
            ||.|.|   .||.|.         :|::  .|:|..:|   ::|:.....:..|...|.     .
Human    55 GAVAQG---YVPHNY---------LAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVS 107

  Fly   593 YQPTMD-VLSLLDQQ------IKAPAVARLNSLGPNASTES--EMASYLHRKCSGTPSTPSATEV 648
            .:|:.| |||:.|.|      |...|..||: |....|..|  |:.:| ||    ..|......:
Human   108 EKPSADYVLSVRDTQAVRHYKIWRRAGGRLH-LNEAVSFLSLPELVNY-HR----AQSLSHGLRL 166

  Fly   649 EAAKLRFFIEP-----------EKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLS 701
            .|...:...||           |:..|.|::|.|.||.|..| |         :.|::||||::|
Human   167 AAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLW---------KDRVQVAIKVIS 222

  Fly   702 DEHSNKQEFLR-EASVMMRLEHKCIVRLIGIAK-GEMLMMVQELAPLGSMLQYILDHGHEITANA 764
            .::...|:.|: |...|.:|.||.|:.|..:.. |:.:.::.||...||:|:.:.|...::...:
Human   223 RDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVS 287

  Fly   765 ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRW 829
            ||...|.|:|.||.|||||:::||||||||||:......|:.|||::|.::   .:...:.....
Human   288 ELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK---EDVYLSHDHNI 349

  Fly   830 PIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPA 894
            |.:|.|||:.:.|.:|..|||||||:.:.||||.|..||..:||.:|...||:|.|:|.|..||.
Human   350 PYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPP 414

  Fly   895 YIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQN 929
            .::.:|.:||...|:.||.|..|.|..:....|:|
Human   415 SVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYEN 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	99/261 (38%)
		PTKc_Syk_like	666..926	CDD:270650	98/262 (37%)
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	7/25 (28%)
		SH2_PTK6_Brk	75..174	CDD:198221	25/104 (24%)
		Linker	171..190		2/18 (11%)
		PTKc_Srm_Brk	184..444	CDD:133248	100/271 (37%)
		STYKc	192..441	CDD:214568	99/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810