DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and fynb

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001025140.1 Gene:fynb / 574422 ZFINID:ZDB-GENE-050706-89 Length:544 Species:Danio rerio


Alignment Length:582 Identity:152/582 - (26%)
Similarity:240/582 - (41%) Gaps:119/582 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 VSLKYPVPPQPKPEVPSF-------ATIPRSNMKPKAASP--ATPPTPVSPHSHHQHPHVPALTI 452
            |..:|.|.|.|: ..|:|       |.||..|....||.|  .|....:|..:|..         
Zfish    27 VGYRYGVDPTPQ-HYPAFSGTGTAVAAIPNYNNFHGAAVPQGMTVFGGISTSTHQG--------- 81

  Fly   453 TKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPML 517
            |.:.:.....::|         .||:|..                      |.||.:|.......
Zfish    82 TLRTRGGTGVTLF---------VALYDYE----------------------ARTEDDLSFRKGEK 115

  Fly   518 KSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIER 582
            ..:..|||...::|..:|..|.......|..|             ....:||..||.|    :.|
Zfish   116 FQIINSTEGDWWDARSLTTGGTGYIPSNYVAP-------------VDSIQAEDWYFGK----LGR 163

  Fly   583 ERA-----------GQWIGNGYQPTMDVLSL--------LDQQIKAPAVARLNSLGPNASTES-- 626
            :.|           |.::....:.|....||        ....:|...:.:|:|.|...:|.:  
Zfish   164 KDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDSGGYYITTRAQF 228

  Fly   627 ----EMASYLHRKCSGT---------PSTPSATEVEA-AKLRFFIEPEKLVLDREIGHGEFGSVH 677
                ::..:...:.:|.         ...|..|::.. .|..:.|..|.|.|.:.:|:|:||.|.
Zfish   229 ETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVW 293

  Fly   678 SG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQ 741
            .| |         ....:||||.|.....:.:.||.||.:|.:|.|..:|:|..:...|.:.:|.
Zfish   294 MGTW---------NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVT 349

  Fly   742 ELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKIS 806
            |....||:|.::.|..........|...|:|:|.||.|:|..:::||||.:.|||:......||:
Zfish   350 EYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIA 414

  Fly   807 DFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEI 871
            |||::|.:.  ..||...||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..:
Zfish   415 DFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGM 477

  Fly   872 SNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            :|.:.::.|:.|.|:..|..||:.::.:|..|||:..::||||.||..|.     |.:|.||
Zfish   478 NNREVLEQVERGYRMQCPQDCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQ 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 91/259 (35%)
PTKc_Syk_like 666..926 CDD:270650 91/265 (34%)
fynbNP_001025140.1 SH3_Fyn_Yrk 92..147 CDD:212939 15/85 (18%)
SH2_Src_Fyn_isoform_a_like 152..252 CDD:198281 17/103 (17%)
PKc_like 268..541 CDD:304357 99/283 (35%)
Pkinase_Tyr 278..527 CDD:285015 91/259 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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