DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and btk

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_021336920.1 Gene:btk / 568653 ZFINID:ZDB-GENE-070531-1 Length:640 Species:Danio rerio


Alignment Length:735 Identity:191/735 - (25%)
Similarity:295/735 - (40%) Gaps:206/735 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 GYVPLHEAAKHGNLEAVQ--ELLLAE--APPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPA 281
            |||         ::|.::  |::|.|  |||     ...:||.:..:.|..        |....:
Zfish    54 GYV---------DIEKIRCVEVVLPEDSAPP-----DRHYPFQIVYDEGPL--------YVFAKS 96

  Fly   282 NTTRDQWYHGTLTREEAVAILKKHAKELLAK-QPEVDTSGCFLVRYSESPAASGLVLTLLCDQVV 345
            :..|..|.|      |...:::.: |:|:.| .|      ||   :.:.       :...|.|.|
Zfish    97 DQIRKHWIH------ELKNVVRFN-KDLMQKYHP------CF---WEDG-------VWKCCLQEV 138

  Fly   346 KNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPE 410
            |                |:.|.:.|...:|          ..|.|.|...  ..:.|:||.|:.|
Zfish   139 K----------------QAMGCRVLETKNG----------GVFKRGSKNR--DSRKPLPPTPEEE 175

  Fly   411 VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTI--TKKKQKENSSSMFNTLRLTSP 473
                        ||....|..||.|            ||.:|  |...:.|.:....|.|.|...
Zfish   176 ------------KPARPLPPEPPMP------------PAFSIGMTVIAEYEYAPMTTNDLELRKD 216

  Fly   474 KK----ALFDMNSLRKNKSKGKRSDSESS-VSGSLAGTEQ--------ELQAAAPMLKSLSFSTE 525
            ::    .:.|.|..:.....||.....|: :..:|.|.|:        ....|..:||       
Zfish   217 EEYTLLEISDPNWFKAKDKYGKEGYIPSNYIVQALNGLEKYDWYCKNINRSQAENLLK------- 274

  Fly   526 FSTFNADG---VTGSG-----------AAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKS 576
              |.|.||   |..||           ..|.||.....|:   ..|.|....|...||...||  
Zfish   275 --TENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRH---YNILLTADGQFYLAEKHNFT-- 332

  Fly   577 DVAIERERAGQWIGNGYQPTMDVLSLLD--QQIKAPAVARLNSLGPNASTESEMASYLHRKCSGT 639
                                 ::..|::  |...|..|:||..:..|             :....
Zfish   333 ---------------------NIPELINYHQHNAAGLVSRLKYIVSN-------------RAQNA 363

  Fly   640 PSTPSATEVEAAKLRF---FIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKML 700
            |.|        |.|.:   .|:|.:|...||:|:|:||.|..| |         :.|.:|||||:
Zfish   364 PCT--------AGLGYGSWEIDPRQLTFIRELGNGQFGVVKYGKW---------QGRHDVAIKMV 411

  Fly   701 SDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANA 764
            .:...::.:|:.||.|||:|.|..:|:|.|: .|...:.:|.|....|.:|.|:.:.....|:.|
Zfish   412 KEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIA 476

  Fly   765 ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRW 829
            .|:: ...::.||.|||:..|:||||||||.|:.:....|::|||:||.:.  ..||..:.|.::
Zfish   477 LLEM-CKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVL--DDEYTSSVGSKF 538

  Fly   830 PIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPA 894
            |:||..||......||..||:|:|||.:||:::.|..||...:|.:.::.:.:|.||.:|.:...
Zfish   539 PVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANE 603

  Fly   895 YIYAVMQSCWKERPKDRPTF 914
            .::|:|.|||.|||.:||||
Zfish   604 NVFAIMNSCWHERPDERPTF 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125 5/21 (24%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560 8/29 (28%)
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 7/27 (26%)
Ank_4 224..274 CDD:290365 10/53 (19%)
SH2_Cterm_shark_like 287..395 CDD:198211 20/108 (19%)
TyrKc 662..921 CDD:197581 95/255 (37%)
PTKc_Syk_like 666..926 CDD:270650 94/251 (37%)
btkXP_021336920.1 PH_Btk 6..145 CDD:269944 30/151 (20%)
SH3 195..249 CDD:327375 10/53 (19%)
SH2 252..357 CDD:326550 29/139 (21%)
PKc_like 376..630 CDD:328722 97/260 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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