DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and csk

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001071067.1 Gene:csk / 556454 ZFINID:ZDB-GENE-061103-493 Length:450 Species:Danio rerio


Alignment Length:637 Identity:137/637 - (21%)
Similarity:216/637 - (33%) Gaps:285/637 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 WYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASG-LVLTLLCDQVVKNFRIS 351
            |:||.:|||:|         |.|...||   :|.||||  ||....| ..|.:.||..|:::|| 
Zfish    82 WFHGKITREQA---------ERLLYPPE---TGLFLVR--ESTNYPGDYTLCVSCDGKVEHYRI- 131

  Fly   352 QADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFAT 416
               :|.||.         |.||:..|:.::..|:.|:.:.:.||                     
Zfish   132 ---IYHNGK---------LSIDEEEYFENLMQLMEHYTKDADGL--------------------- 163

  Fly   417 IPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMN 481
                                                              ..||..||       
Zfish   164 --------------------------------------------------CTRLIKPK------- 171

  Fly   482 SLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVY 546
                                                                             
Zfish   172 ----------------------------------------------------------------- 171

  Fly   547 NVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPA 611
                           |.:.|.|..:.|::|..|:.|                             
Zfish   172 ---------------IMEGTVAAQDEFSRSGWALNR----------------------------- 192

  Fly   612 VARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSV 676
                                                            ::|.|.:.||.||||.|
Zfish   193 ------------------------------------------------KELKLIQTIGKGEFGDV 209

  Fly   677 HSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI---AKGEMLM 738
            .         .|:....:||:|.:..: :..|.|:.|||||.:|.|..:|:|:|:   .||.:.:
Zfish   210 M---------VGDYRGKKVAVKCIKHD-ATAQAFVAEASVMTQLRHNNLVQLLGVIVEEKGSLYI 264

  Fly   739 MVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQA 803
            :.:.:|. ||::.|:...|..:.....|..::..:...|.|||:.:||||||||||:|::..:.|
Zfish   265 VTEYMAK-GSLVDYLRSRGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNIA 328

  Fly   804 KISDFGMSRSLRPGSTEYQFTQG-GRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPP 867
            |:||||:::       |...||. .:.|::|.:||:.....||..|||||:|:.:||::|.|..|
Zfish   329 KVSDFGLTK-------EASSTQDTAKLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVP 386

  Fly   868 YGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTE 919
            |..|...:.:..|:.|.::..|:.||..:|.:|:.||......||:|..|.|
Zfish   387 YPRIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLRE 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211 34/107 (32%)
TyrKc 662..921 CDD:197581 90/262 (34%)
PTKc_Syk_like 666..926 CDD:270650 88/258 (34%)
cskNP_001071067.1 SH3_CSK 11..67 CDD:212703
SH2_csk_like 78..175 CDD:198190 41/277 (15%)
PTKc_Csk 188..443 CDD:133213 92/346 (27%)
STYKc 195..440 CDD:214568 90/262 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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