DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Src64B

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	111/346 - (32%)
Similarity:	182/346 - (52%)	Gaps:	37/346 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 ERAGQWIG-NGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSAT 646
            :..|.:|. |...|::..|.:        |.::.|:||        :...|.|.|  ....|...
  Fly   222 DNGGYYIATNQTFPSLQALVM--------AYSKENALG--------LCHILSRPC--PKPQPQMW 268

  Fly   647 EVEAAKLR--FFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQ 708
            :: ..:||  :.|...::.|.|::|.|.||.|..| |         .:.::||:|.|.:...:..
  Fly   269 DL-GPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKW---------RNSIDVAVKTLREGTMSTA 323

  Fly   709 EFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQ 772
            .||:||::|.:..|..:|.|..: ::.|.:.:|||....||:|.::.:.........:|...|:|
  Fly   324 AFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQ 388

  Fly   773 IACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPE 837
            :|.||.||||:..:||||||||:|:...:.|||.|||::|.:  ...||...||.|:|::|.|||
  Fly   389 VASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI--ADDEYCPKQGSRFPVKWTAPE 451

  Fly   838 SFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQP--NLCPAYIYAVM 900
            :...|.||..|||||:|:.:.|:|:.|..||..:.:.:.|:.::.|.|:|:|  :..|..||.::
  Fly   452 AIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLL 516

  Fly   901 QSCWKERPKDRPTFVYLTEFF 921
            ..||...|:.||||.:|..:|
  Fly   517 LQCWDAVPEKRPTFEFLNHYF 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	94/262 (36%)
		PTKc_Syk_like	666..926	CDD:270650	94/260 (36%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827	10/52 (19%)
		STYKc	285..537	CDD:214568	94/262 (36%)
		PTKc_Src_like	289..538	CDD:270630	94/260 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890