DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and Abl

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster


Alignment Length:734 Identity:163/734 - (22%)
Similarity:253/734 - (34%) Gaps:266/734 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 HEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQ------------------------ 266
            |....|.||||     |.::.|||...:|.....|..:|.:                        
  Fly   121 HPGKYHMNLEA-----LLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSS 180

  Fly   267 -TAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESP 330
             |:|.|            :..:|     |.:|          .|||..||.|....|:..|.   
  Fly   181 TTSVFE------------SAHRW-----TSKE----------NLLAPGPEEDDPQLFVALYD--- 215

  Fly   331 AASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDG------PYWPSVEHLIAHFM 389
                                           .|:||...|.:..|      .|..|.|...||..
  Fly   216 -------------------------------FQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD 249

  Fly   390 RFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITK 454
            ..:.|.               |||              :..||...:..||.:..|         
  Fly   250 SGNVGW---------------VPS--------------NYVTPLNSLEKHSWYHGP--------- 276

  Fly   455 KKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKS 519
                                        :.:|.::...|   |.::||....|.|   ::|..:|
  Fly   277 ----------------------------ISRNAAEYLLS---SGINGSFLVRESE---SSPGQRS 307

  Fly   520 LSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERER 584
            :|...|                 |.||:...:..|                              
  Fly   308 ISLRYE-----------------GRVYHYRISEDP------------------------------ 325

  Fly   585 AGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSL------------GPNASTESEMASYLHRKCS 637
                               |.::.....|:.|:|            |....|.....:....|.:
  Fly   326 -------------------DGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPT 371

  Fly   638 GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLS 701
            ..|.:|...|.|..:       ..:::..::|.|::|.|:.. |  ::.|.      .||:|.|.
  Fly   372 VFPLSPEPDEWEICR-------TDIMMKHKLGGGQYGEVYEAVW--KRYGN------TVAVKTLK 421

  Fly   702 DEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYILDHGHEITANAE 765
            ::....::||.||::|..::|..:|:|||:...| ...::.|....|::|.::...|.|......
  Fly   422 EDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVA 486

  Fly   766 LKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWP 830
            |...|:|||.||.||||::::||||||||.|:......|::|||::|.:|..:  |....|.::|
  Fly   487 LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT--YTAHAGAKFP 549

  Fly   831 IRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAY 895
            |:|.|||......||..||||:|||.:||:.:.|..||..|...|....:|.|.|:.:|..||..
  Fly   550 IKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPE 614

  Fly   896 IYAVMQSCWKERPKDRPTF 914
            :|.:|:.||:....|||||
  Fly   615 VYDLMRQCWQWDATDRPTF 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125 6/14 (43%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560 7/20 (35%)
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 7/18 (39%)
Ank_4 224..274 CDD:290365 16/72 (22%)
SH2_Cterm_shark_like 287..395 CDD:198211 21/113 (19%)
TyrKc 662..921 CDD:197581 91/255 (36%)
PTKc_Syk_like 666..926 CDD:270650 91/251 (36%)
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 16/116 (14%)
SH2_ABL 268..363 CDD:198189 24/203 (12%)
PTKc_Abl 382..644 CDD:270645 92/269 (34%)
Pkinase_Tyr 389..640 CDD:285015 91/255 (36%)
FABD 1584..1723 CDD:197885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468393
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24418
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

Return to query results.
Submit another query.