DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and zap70

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001006825.1 Gene:zap70 / 448557 XenbaseID:XB-GENE-956409 Length:609 Species:Xenopus tropicalis


Alignment Length:920 Identity:212/920 - (23%)
Similarity:325/920 - (35%) Gaps:366/920 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 MKWYHGNLSREAADELLK-QGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH-------- 63
            :.:|:|::||..|:|.|| .|..||.||:|:.....|.:|||::......||.|.|.        
 Frog     8 LPFYYGSISRADAEEYLKLGGMMDGLFLLRQCLRTLGGYVLSMVYNLHFHHYPVERQLNGTYAIA 72

  Fly    64 GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRAT 128
            ||             |...|...|.:||.:.|:||...|..|.        .|..||        
 Frog    73 GG-------------KAHCGPAELCEYYSKDADGLCCTLRRPC--------NRPAGV-------- 108

  Fly   129 SKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHY 193
                        :|....||                                |..|         
 Frog   109 ------------ECQAGVFD--------------------------------NMRD--------- 120

  Fly   194 AARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPF 258
                   :.:|..:.....::|                   :|:::.::::||            
 Frog   121 -------NMMREYVRQTWKLEG-------------------DALEQAIISQAP------------ 147

  Fly   259 DLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFL 323
            .:.|....||.|              |..|||||::|:||...|...|      ||:    |.||
 Frog   148 QVEKLIATTAHE--------------RMAWYHGTISRDEAERKLYSGA------QPD----GKFL 188

  Fly   324 VRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHF 388
            :|  |........|:::..:.|.:::|.|.   ::|......|:||     ...|..||:|    
 Frog   189 MR--ERKENGTYALSVMYGKTVYHYKIDQD---KSGKYSIPEGTKF-----DTLWQLVEYL---- 239

  Fly   389 MRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTIT 453
                                                                             
 Frog   240 ----------------------------------------------------------------- 239

  Fly   454 KKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLK 518
                |..|..:...|:.:.|....|                       |:|      .||||.  
 Frog   240 ----KLKSDGIMAVLKESCPNSCTF-----------------------SIA------PAAAPP-- 269

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERE 583
                                                   .||.|.|..       :.||      
 Frog   270 ---------------------------------------SLPKIRQAA-------SNSD------ 282

  Fly   584 RAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEV 648
                    ||.|             .|.:.:...|..:.|..               .:|.:...
 Frog   283 --------GYTP-------------EPFIGKSRILPMDTSVY---------------ESPYSDPE 311

  Fly   649 EAAKLRFFIEPEKLVLDR-EIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKML--SDEHSNKQE 709
            |..:.:.|::.|.|::|. |:|.|.||.|..| :.|:|      .:::||||:|  .||.:.:.|
 Frog   312 ELKERKLFVKRELLLIDEVELGSGNFGCVKKGVYKLKK------RQIDVAIKVLKVQDEKNVRDE 370

  Fly   710 FLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIA 774
            .::||.:|.:|::..|||:||:.:.|.||:|.|:|. |..|...|....::...:.:.....|::
 Frog   371 MMKEAEIMHQLDNPYIVRMIGVCEAENLMLVMEMAS-GGPLNKFLGAKKDVIPMSNIVELMHQVS 434

  Fly   775 CGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESF 839
            .||.|||.::||||||||||:|:..:|.|||||||:|::|....:.|:....|:||::|||||..
 Frog   435 IGMKYLEGKNFVHRDLAARNVLMVNQHYAKISDFGLSKALAADDSYYKAKSFGKWPLKWYAPECI 499

  Fly   840 NLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCW 904
            |...||..|||||:|:|:||.|:.|..||.::...:.:..::..|||..|..||..:|.||..||
 Frog   500 NYRKFSSRSDVWSYGITMWEAFTYGQKPYKKLKGTEVMSFIERNERLACPAGCPPEMYQVMLDCW 564

  Fly   905 KERPKDRPTF 914
            ..:.:|||.|
 Frog   565 IFKMEDRPNF 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210 27/91 (30%)
Ank_2 <112..184 CDD:289560 7/71 (10%)
ANK 117..241 CDD:238125 10/123 (8%)
ANK repeat 124..151 CDD:293786 3/26 (12%)
ANK repeat 153..184 CDD:293786 1/30 (3%)
Ank_2 158..247 CDD:289560 6/88 (7%)
ANK repeat 186..217 CDD:293786 2/30 (7%)
ANK repeat 220..245 CDD:293786 1/24 (4%)
Ank_4 224..274 CDD:290365 7/49 (14%)
SH2_Cterm_shark_like 287..395 CDD:198211 29/107 (27%)
TyrKc 662..921 CDD:197581 104/257 (40%)
PTKc_Syk_like 666..926 CDD:270650 102/253 (40%)
zap70NP_001006825.1 SH2_N-SH2_Zap70_Syk_like 8..111 CDD:198191 37/143 (26%)
SH2_C-SH2_Zap70 152..256 CDD:198265 36/210 (17%)
PKc_like 321..589 CDD:389743 105/261 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 210 1.000 Domainoid score I2766
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 282 1.000 Inparanoid score I2815
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D345546at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm47958
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2868
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.970

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