DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and MATK

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_002369.2 Gene:MATK / 4145 HGNCID:6906 Length:508 Species:Homo sapiens


Alignment Length:283 Identity:106/283 - (37%)
Similarity:162/283 - (57%) Gaps:17/283 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   642 TPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN 706
            |.||.| |.|:..:.:..:.|.|..:||.||||:|..|..|.:         :||:|.:..: ..
Human   217 TKSAEE-ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQ---------KVAVKNIKCD-VT 270

  Fly   707 KQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWAS 771
            .|.||.|.:||.:::|:.:|||:|:...:.|.:|.|....|:::.::...|..:...|:|..::.
Human   271 AQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL 335

  Fly   772 QIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAP 836
            .:|.||.||||:..|||||||||||::....||:||||::::.|.|      ....|.|::|.||
Human   336 HVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKG------LDSSRLPVKWTAP 394

  Fly   837 ESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQ 901
            |:...|.|:..||||||||.:||:||.|..||.::|..:..:.|:.|.|:..|..||..::.:|.
Human   395 EALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMS 459

  Fly   902 SCWKERPKDRPTFVYLTEFFARD 924
            |||:..|..||.|..|.|..||:
Human   460 SCWEAEPARRPPFRKLAEKLARE 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 98/258 (38%)
PTKc_Syk_like 666..926 CDD:270650 98/259 (38%)
MATKNP_002369.2 SH3_CHK 51..109 CDD:212745
SH3 domain 55..106
SH2_csk_like 119..216 CDD:198190
SH2 domain 123..213
PTKc_Chk 229..482 CDD:270666 99/268 (37%)
catalytic domain 236..479 98/258 (38%)
STYKc 236..479 CDD:214568 98/258 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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