DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Csk

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	943	Identity:	225/943 - (23%)
Similarity:	331/943 - (35%)	Gaps:	272/943 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 ARSKPASFIRTLISAQANVQGRN--IDNGYVP------------LHEAAKHGNLEAVQELLLAEA 245
            ||.||.....:|.:|.|..:.|.  ..:.|.|            ...:|||           ..:
  Fly   150 ARRKPILLCSSLSAAYAPPRRREFYFCDKYAPGPARSTPTTTTTSATSAKH-----------ESS 203

  Fly   246 PPLP-------RTSSGEFPFDLAKEAGQTAVEEFLLNYK-------------LPPANTTRDQWYH 290
            ||:.       |.:..:|....||...|...:.||.|.:             |||. .:.::|:.
  Fly   204 PPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPI-ASSEEWFD 267

  Fly   291 GTLTREEAVAILKKHAKELLAK-QPEVDTSGCFLVRYSESPAAS----------------GLVLT 338
                 |||.|....|.|....| :||.:        :.|..|.|                ||:..
  Fly   268 -----EEAQARKTSHEKSQKPKPKPEEN--------HKEKEAISRKASGEGDLITVEIKQGLLRK 319

  Fly   339 LLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLK--- 400
            ............|.|...|||.....|..:      |...|||....|.....:.|.|..|:
  Fly   320 QTATTTTGQAMNSHATATQNGQTTVVGHHR------GFSQPSVTVAAAAATGSTAGDPWFLQTTG 378

  Fly   401 YPVPP--------QPKPE------VPSFATIPRS--------NMKPKAASPATPPTPVSPHSHHQ 443
            :.:||        :|.|:      ..|..|.|.|        ..:...:.|...|..:.||.||.
  Fly   379 HQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHH 443

  Fly   444 -----HP---------------------------HVP---------ALTITKKKQKENSSSMFNT 467
                 ||                           |.|         ..|..:::|::...:..:.
  Fly   444 RENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSI 508

  Fly   468 LRLTSPKKAL---------------------------------------------FDMNSLRKNK 487
            |...:|...:                                             ..:|:.:...
  Fly   509 LSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGM 573

  Fly   488 SKGKRS--DSESSVSGSLAGTE-------QELQAAAPML-------KSLSFSTEFSTFNADGVTG 536
            ...:|:  ....::|||..|:.       |..||:.|..       .|...||...:|:.:|||.
  Fly   574 HGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTA 638

  Fly   537 SGAAAAGEVYNVPRNNTPIEIDLPPIA-------QKTEAEVEYFTKSDVAIERERAGQWIGNGYQ 594
            .....|...::...........|.|.|       .:.|.::........:|.|:.|...:    |
  Fly   639 GSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL----Q 699

  Fly   595 PTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCS--------GTPSTPSATEVEA- 650
            |..|.|.|:.:....|....| .:...:..|.....||..|.:        ......:..|.:|
  Fly   700 PREDGLFLVRESTNFPGDYTL-CVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADAD 763

  Fly   651 -------------AKLRFFIE-----------PE-KLVLDREIGHGEFGSVHSGWLLRKSGAGEE 690
                         .|..|.|.           || :|.|...||.||||.|..| :||..
  Fly   764 GLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLG-ILRNE----- 822

  Fly   691 SRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMVQELAPLGSMLQYIL 754
               :||:|||.||.: .|:||.|||||..|||..:|:.||:. ..:.|.:|.|....||::.|:.
  Fly   823 ---KVAVKMLKDEGA-VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLR 883

  Fly   755 DHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGST 819
            ..|.:.....:..::|...|.||.|||::..|||||||||:|::....||:||||::|.
  Fly   884 SRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE------ 942

  Fly   820 EYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGE 884
            |......|:.||:|.|||:...|.||:.||:||||:.:||::|.|..||..|...|.:|.|:.|.
  Fly   943 ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGY 1007

  Fly   885 RLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917
            ::..|..||..||.:|:..|...|..||||..|
  Fly  1008 KMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125	13/59 (22%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560	13/65 (20%)
		ANK repeat	186..217	CDD:293786	7/21 (33%)
		ANK repeat	220..245	CDD:293786	5/36 (14%)
		Ank_4	224..274	CDD:290365	12/68 (18%)
		SH2_Cterm_shark_like	287..395	CDD:198211	26/124 (21%)
		TyrKc	662..921	CDD:197581	105/257 (41%)
		PTKc_Syk_like	666..926	CDD:270650	103/253 (41%)
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	16/101 (16%)
		PTKc_Csk_like	793..1047	CDD:270635	107/264 (41%)
		STYKc	800..1044	CDD:214568	105/257 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840