DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and LYN

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:XP_011515831.1 Gene:LYN / 4067 HGNCID:6735 Length:682 Species:Homo sapiens


Alignment Length:752 Identity:185/752 - (24%)
Similarity:304/752 - (40%) Gaps:167/752 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 LAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHA 306
            :.:.|..||.....|...|.::||             |..:|.|.    ..|:|:.:|.     :
Human    36 VVDVPAKPRLLWRSFRPSLQEKAG-------------PGCSTPRS----CRLSRQVSVP-----S 78

  Fly   307 KELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRI----SQADLYQNGNKVQSGGS 367
            |......|...|.|  ..:...|| .|||           |.:|    |..||     ..:...|
Human    79 KPCATATPNTQTLG--RDQTVTSP-PSGL-----------NMQIRAPGSSWDL-----SAEPRDS 124

  Fly   368 KFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYP--------VPPQPKPEVPSFATIPRSNMKP 424
            :||....||...|:..      |.:.| |.:|:.|        ..|.|.|..|..|:.......|
Human   125 QFLSRRAGPRCRSLPG------RGASG-PDALQPPARGKRGGRATPGPAPAAPRRASSVPGQQPP 182

  Fly   425 KA----ASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKK------ALFD 479
            ..    ..|..|||..|  ||...|  |.....:::..|:........:...|::      ||:.
Human   183 HTQVLLGRPVAPPTLNS--SHRGAP--PPRNFHRERVPESQLLPGQRFQTKDPEEQGDIVVALYP 243

  Fly   480 MNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGE 544
            .:.:..:....|:.:.           .:.|:......|:.|..|:...|               
Human   244 YDGIHPDDLSFKKGEK-----------MKVLEEHGEWWKAKSLLTKKEGF--------------- 282

  Fly   545 VYNVPRNNTPIEIDLPPIAQKTEAEV-EYFTKSDVAIERER--------AGQWI--------GNG 592
               :|.|.         :|:....|. |:|.|.....:.||        ||.::        |:.
Human   283 ---IPSNY---------VAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSF 335

  Fly   593 YQPTMDVLSLLDQQIKAPAVARLNSLGPNASTE------SEMASYLHRKCSG----------TPS 641
            .....|...:....||...:..|::.|...|..      |:|..:..::..|          :|.
Human   336 SLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPK 400

  Fly   642 TPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN 706
            .....:.:|    :.|..|.:.|.:.:|.|:||.|..|:.        .:..:||:|.|.....:
Human   401 PQKPWDKDA----WEIPRESIKLVKRLGAGQFGEVWMGYY--------NNSTKVAVKTLKPGTMS 453

  Fly   707 KQEFLREASVMMRLEHKCIVRLIG-IAKGEMLMMVQELAPLGSMLQYI-LDHGHEITANAELKVW 769
            .|.||.||::|..|:|..:|||.. :.:.|.:.::.|....||:|.:: .|.|.::.. .:|..:
Human   454 VQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLL-PKLIDF 517

  Fly   770 ASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWY 834
            ::|||.||.|:|.::::||||.|.|:|::.....||:|||::|.:.  ..||...:|.::||:|.
Human   518 SAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE--DNEYTAREGAKFPIKWT 580

  Fly   835 APESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAV 899
            |||:.|.|.|:..|||||||:.::|:.:.|..||...:|.|.:..:..|.|:|:...||..:|.:
Human   581 APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDI 645

  Fly   900 MQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            |:.||||:.::||||.|    |.:|: |.:..||..|
Human   646 MKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560 0/4 (0%)
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 0/2 (0%)
Ank_4 224..274 CDD:290365 7/31 (23%)
SH2_Cterm_shark_like 287..395 CDD:198211 24/111 (22%)
TyrKc 662..921 CDD:197581 92/264 (35%)
PTKc_Syk_like 666..926 CDD:270650 93/266 (35%)
LYNXP_011515831.1 SH3_Lyn 237..292 CDD:212937 11/92 (12%)
SH2_Src_Lyn 295..395 CDD:198227 18/99 (18%)
PTKc_Lyn 409..680 CDD:270657 98/285 (34%)
Pkinase_Tyr 417..667 CDD:285015 91/260 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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