DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and LYN

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_002341.1 Gene:LYN / 4067 HGNCID:6735 Length:512 Species:Homo sapiens


Alignment Length:523 Identity:141/523 - (26%)
Similarity:237/523 - (45%) Gaps:93/523 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   487 KSKGKRSDSESSV---SGSLAGTEQELQAAAP-------------MLKSLSFSTE---------F 526
            |||||.|.|:..|   :..:..||:.:....|             :|....|.|:         .
Human     5 KSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVV 69

  Fly   527 STFNADGVTGSGAA-----------AAGEVYNVPRNNTPIEIDLPP--IAQKTEAEV-EYFTKSD 577
            :.:..||:.....:           ..||.:......|..|..:|.  :|:....|. |:|.|..
Human    70 ALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDI 134

  Fly   578 VAIERER--------AGQWI--------GNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTE- 625
            ...:.||        ||.::        |:......|...:....||...:..|::.|...|.. 
Human   135 TRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRI 199

  Fly   626 -----SEMASYLHRKCSG----------TPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGS 675
                 |:|..:..::..|          :|......:.:|    :.|..|.:.|.:.:|.|:||.
Human   200 TFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDA----WEIPRESIKLVKRLGAGQFGE 260

  Fly   676 VHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIG-IAKGEMLMM 739
            |..|:.        .:..:||:|.|.....:.|.||.||::|..|:|..:|||.. :.:.|.:.:
Human   261 VWMGYY--------NNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYI 317

  Fly   740 VQELAPLGSMLQYI-LDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQA 803
            :.|....||:|.:: .|.|.::.. .:|..:::|||.||.|:|.::::||||.|.|:|::.....
Human   318 ITEYMAKGSLLDFLKSDEGGKVLL-PKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC 381

  Fly   804 KISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPY 868
            ||:|||::|.:.  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.::|:.:.|..||
Human   382 KIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPY 444

  Fly   869 GEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQ 928
            ...:|.|.:..:..|.|:|:...||..:|.:|:.||||:.::||||.|    |.:|: |.:..||
Human   445 PGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQ 509

  Fly   929 NLP 931
            ..|
Human   510 QQP 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/266 (35%)
LYNNP_002341.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 14/56 (25%)
SH3_Lyn 67..122 CDD:212937 8/54 (15%)
SH2_Src_Lyn 125..225 CDD:198227 18/99 (18%)
PTKc_Lyn 239..510 CDD:270657 98/285 (34%)
Blue background indicates that the domain is not in the aligned region.

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