Protein Alignment Shark and syk

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_005155595.1
• Gene: syk / 405769
• ZFINID: ZDB-GENE-040702-3
• Length: 608
• Species: Danio rerio
• Alignment Length: 921
• Identity: 222/921 - (24%)
• Similarity: 338/921 - (36%)
• Gaps: 350/921 - (38%)

  Fly     8 MKWYHGNLSREAADELLKQGYE-DGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH-------- 63
            :.::.||::||.::..|:||.. ||.:|:|:|.:..|.:.|||....:..||.:.|.
Zfish     8 LPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIA 72

  Fly    64 GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRAT 128
            ||:.....||             :::|:.|.::||...|..|..|   |..|
Zfish    73 GGKSHRTPID-------------VINYHSQESDGLICLLKKPFHR---PRGT------------- 108

  Fly   129 SKNESKV-VFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLH 192
               |.|| .||         |.|.|
Zfish   109 ---EPKVGPFE---------DLKEQ---------------------------------------- 121

  Fly   193 YAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFP 257
                     .||..:....|::|                   .|:.:.::::.|
Zfish   122 ---------LIRQYVEQTWNLKG-------------------SALDQAIISQRP----------- 147

  Fly   258 FDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCF 322
             .|.|....||.|      |:|        |:||.:.||::...|...::          .:|.|
Zfish   148 -QLEKLIATTAHE------KMP--------WFHGKIDREDSELRLLNTSR----------VNGKF 187

  Fly   323 LVRYSESPAAS-GLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIA 386
            |:|..|:...: ...|.||.:..|.::||         :|.::|.   |.|.||..:.::..|:.
Zfish   188 LIRQRENSGRNESYALCLLHNNQVMHYRI---------DKDRAGK---LSIPDGKKFDTLWQLVE 240

  Fly   387 HFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALT 451
            |   :||.....|:......|:|                              |||
Zfish   241 H---YSYKPDGLLRVLTETCPRP------------------------------SHH--------- 263

  Fly   452 ITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPM 516
                                                       ||...:|.:..          .
Zfish   264 -------------------------------------------SERGATGGIIS----------R 275

  Fly   517 LKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIE 581
            |||.||..          .|....:|...|.:..|.                      |.|.:.:
Zfish   276 LKSYSFPK----------PGQKKGSAENPYKITPNG----------------------KDDYSKQ 308

  Fly   582 RERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSAT 646
                    ||    .:|....:|.|:                .||..|.         |....:|
Zfish   309 --------GN----FLDSAMPMDTQV----------------YESPYAD---------PDELRST 336

  Fly   647 EVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN---KQ 708
            :|..:.|        .:.|.|:|.|.||:|..|....|     :::..||:|:|.::..|   |.
Zfish   337 KVNRSDL--------TLEDGELGSGNFGTVLRGVYQMK-----KTQKVVAVKILKNDDDNAAVKD 388

  Fly   709 EFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQI 773
            |.||||:||.:|::..|||:|||.:.|.||:|.|||.||.:.:::..:.|....|  |.....|:
Zfish   389 EMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKN--LTELVHQV 451

  Fly   774 ACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPES 838
            :.||.|||..:||||||||||:||..:|.|||||||:|::|......|:....|:||::|||||.
Zfish   452 SMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPEC 516

  Fly   839 FNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSC 903
            .|...||..||||||||.:||.||.|..||..:...:.|:::::|:|:..|..||..:|.:|:.|
Zfish   517 MNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKC 581

  Fly   904 WKERPKDRPTF 914
            |..:|.:||.|
Zfish   582 WTYKPDERPGF 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	23/91 (25%)
		ANKYR	<94..317	CDD:440430	34/223 (15%)
		ANK repeat	124..151	CDD:293786	6/27 (22%)
		ANK repeat	153..184	CDD:293786	0/30 (0%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	1/24 (4%)
		SH2_Cterm_shark_like	287..395	CDD:198211	27/108 (25%)
		PTKc_Syk_like	666..926	CDD:270650	109/252 (43%)
syk	XP_005155595.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	33/134 (25%)
		SH2_C-SH2_Syk_like	159..260	CDD:198264	32/139 (23%)
		PTKc_Syk	348..604	CDD:133247	109/252 (43%)