DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shark and syk

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_005155595.1	Gene:	syk / 405769	ZFINID:	ZDB-GENE-040702-3	Length:	608	Species:	Danio rerio

Alignment Length:	921	Identity:	222/921 - (24%)
Similarity:	338/921 - (36%)	Gaps:	350/921 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MKWYHGNLSREAADELLKQGYE-DGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH-------- 63
            :.::.||::||.::..|:||.. ||.:|:|:|.:..|.:.|||....:..||.:.|.
Zfish     8 LPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIA 72

  Fly    64 GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRAT 128
            ||:.....||             :::|:.|.::||...|..|..|   |..|
Zfish    73 GGKSHRTPID-------------VINYHSQESDGLICLLKKPFHR---PRGT------------- 108

  Fly   129 SKNESKV-VFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLH 192
               |.|| .||         |.|.|
Zfish   109 ---EPKVGPFE---------DLKEQ---------------------------------------- 121

  Fly   193 YAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFP 257
                     .||..:....|::|                   .|:.:.::::.|
Zfish   122 ---------LIRQYVEQTWNLKG-------------------SALDQAIISQRP----------- 147

  Fly   258 FDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCF 322
             .|.|....||.|      |:|        |:||.:.||::...|...::          .:|.|
Zfish   148 -QLEKLIATTAHE------KMP--------WFHGKIDREDSELRLLNTSR----------VNGKF 187

  Fly   323 LVRYSESPAAS-GLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIA 386
            |:|..|:...: ...|.||.:..|.::||         :|.::|.   |.|.||..:.::..|:.
Zfish   188 LIRQRENSGRNESYALCLLHNNQVMHYRI---------DKDRAGK---LSIPDGKKFDTLWQLVE 240

  Fly   387 HFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALT 451
            |   :||.....|:......|:|                              |||
Zfish   241 H---YSYKPDGLLRVLTETCPRP------------------------------SHH--------- 263

  Fly   452 ITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPM 516
                                                       ||...:|.:..          .
Zfish   264 -------------------------------------------SERGATGGIIS----------R 275

  Fly   517 LKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIE 581
            |||.||..          .|....:|...|.:..|.                      |.|.:.:
Zfish   276 LKSYSFPK----------PGQKKGSAENPYKITPNG----------------------KDDYSKQ 308

  Fly   582 RERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSAT 646
                    ||    .:|....:|.|:                .||..|.         |....:|
Zfish   309 --------GN----FLDSAMPMDTQV----------------YESPYAD---------PDELRST 336

  Fly   647 EVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSN---KQ 708
            :|..:.|        .:.|.|:|.|.||:|..|....|     :::..||:|:|.::..|   |.
Zfish   337 KVNRSDL--------TLEDGELGSGNFGTVLRGVYQMK-----KTQKVVAVKILKNDDDNAAVKD 388

  Fly   709 EFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQI 773
            |.||||:||.:|::..|||:|||.:.|.||:|.|||.||.:.:::..:.|....|  |.....|:
Zfish   389 EMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKN--LTELVHQV 451

  Fly   774 ACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPES 838
            :.||.|||..:||||||||||:||..:|.|||||||:|::|......|:....|:||::|||||.
Zfish   452 SMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPEC 516

  Fly   839 FNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSC 903
            .|...||..||||||||.:||.||.|..||..:...:.|:::::|:|:..|..||..:|.:|:.|
Zfish   517 MNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKC 581

  Fly   904 WKERPKDRPTF 914
            |..:|.:||.|
Zfish   582 WTYKPDERPGF 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	23/91 (25%)
		Ank_2	<112..184	CDD:289560	10/72 (14%)
		ANK	117..241	CDD:238125	13/124 (10%)
		ANK repeat	124..151	CDD:293786	6/27 (22%)
		ANK repeat	153..184	CDD:293786	0/30 (0%)
		Ank_2	158..247	CDD:289560	5/88 (6%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	1/24 (4%)
		Ank_4	224..274	CDD:290365	7/49 (14%)
		SH2_Cterm_shark_like	287..395	CDD:198211	27/108 (25%)
		TyrKc	662..921	CDD:197581	110/256 (43%)
		PTKc_Syk_like	666..926	CDD:270650	109/252 (43%)
syk	XP_005155595.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	33/134 (25%)
		SH2_C-SH2_Syk_like	159..260	CDD:198264	32/139 (23%)
		PTKc_Syk	348..604	CDD:133247	109/252 (43%)
		Pkinase_Tyr	349..599	CDD:285015	109/251 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2722
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3085
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D345546at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105357
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.830