DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and fyna

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001315092.1 Gene:fyna / 373872 ZFINID:ZDB-GENE-030903-5 Length:537 Species:Danio rerio


Alignment Length:575 Identity:153/575 - (26%)
Similarity:239/575 - (41%) Gaps:118/575 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   423 KPKAASPATP--PTPVSPHSHHQH------PHVPALTITKKKQKENSSSMFNTLRLTSPKKALFD 479
            |.|.|:..|.  .|.||.|:.:::      .|.|:..:|                      |:.:
Zfish     7 KDKEATKLTDERETSVSQHAGYRYGSDPTPQHYPSFGVT----------------------AIPN 49

  Fly   480 MNSLRKNKSK------GKRSDSESSVSGSLAGTEQELQAA-----APMLKSLSF----------S 523
            .|:.....|:      |..|.|.|....|..||...|..|     |.....|||          |
Zfish    50 YNNFHAPVSQGVTVFGGVNSSSHSGTLRSRGGTGVTLFVALYDYEARSEDDLSFRKGEKFQILNS 114

  Fly   524 TEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQW 588
            ||...:.|..:|..|.......|..|             ....:||..||.|..   .::...|.
Zfish   115 TEGDWWEARSLTTGGTGYIPSNYVAP-------------VDSIQAEDWYFGKLG---RKDAERQL 163

  Fly   589 IGNG----------YQPTMDVLSLLDQ--------QIKAPAVARLNSLGPNASTES------EMA 629
            :.||          .:.|....||..|        .:|...:.:|::.|...:|.:      ::.
Zfish   164 LSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLV 228

  Fly   630 SYLHRKCSGT---------PSTPSATEVEA-AKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLR 683
            .:...:.:|.         ...|...::.. .|..:.|..|.|.|.:.:|:|:||.|..| |   
Zfish   229 HHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTW--- 290

  Fly   684 KSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGS 748
                  ....:||:|.|.....:.:.||.||.:|.:|.|..:|:|..:...|.:.:|.|....||
Zfish   291 ------NGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMSKGS 349

  Fly   749 MLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRS 813
            :|.::.|..........|...|:|:|.||.|:|..:::||||.:.|||:......||:|||::|.
Zfish   350 LLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARL 414

  Fly   814 LRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIK 878
            :.  ..||...||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::|.:.::
Zfish   415 IE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE 477

  Fly   879 LVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            .|:.|.|:|.|..||:.::.:|..|||..|::||||.||..|.     |.:|.||
Zfish   478 QVERGYRMPCPQDCPSSLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQYQ 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 92/265 (35%)
fynaNP_001315092.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..34 5/20 (25%)
SH3_Fyn_Yrk 85..140 CDD:212939 13/54 (24%)
SH2_Src_Fyn_isoform_a_like 145..245 CDD:198281 17/102 (17%)
PTKc_Fyn 261..534 CDD:270655 100/283 (35%)
Blue background indicates that the domain is not in the aligned region.

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