DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Fak

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster

Alignment Length:	916	Identity:	217/916 - (23%)
Similarity:	329/916 - (35%)	Gaps:	299/916 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PPHNTRSHGVTNLLH--------RATSKNESKVVFELLKCGYRNFDAKNQDGQT----------- 156
            ||.....:....|:|        :|...|..:.||.:::   |..:....||:|
  Fly    11 PPTKNEINSEEYLIHVHMPNKSFKAVRFNVKETVFHVIR---RTVEDLGTDGRTPSIQRYACRML 72

  Fly   157 ------ALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQG 215
                  .:.||...|.:.:|.|:|..          ||.  :....:..:.....|:.     .|
  Fly    73 NMITKEVIWLARSTSMQKVLSHILTP----------GCS--NVDCPNNQSELDEVLLE-----HG 120

  Fly   216 RNI-DN---------GYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVE 270
            |.| ||         .|||          ..:|||...:      .::..:.|:..|       |
  Fly   121 RRITDNRVWRVELRVRYVP----------NNIQELFEED------KATCFYYFNQVK-------E 162

  Fly   271 EFLLNYKLPPANTTRDQWYHGTLTREEAVAI----LKKHAKELLAKQPEVDTSGCFLVRYSESPA 331
            :|:      .||.|       .:..|.||.:    ::.:.|.:..|.|:....    :.|.|...
  Fly   163 DFI------QANVT-------AIDTEVAVQLCCLGIRHYFKNITVKAPDKKQH----IDYIEKEI 210

  Fly   332 A--SGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHL---------- 384
            .  |.|..:::.....||.:          ..:|.|..|....:|      :|:|
  Fly   211 GFKSFLPQSVIATSKPKNLK----------KLIQVGYKKVYNYND------IEYLTRFFDLLKNI 259

  Fly   385 -IAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPH---SHHQHP 445
             :.:|.:||..|                             .:|...:....|.||   |:..||
  Fly   260 YLTNFEQFSVTL-----------------------------SSAWNISGILHVGPHIGISYQTHP 295

  Fly   446 HVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQEL 510
            ......:.:.|      .:.:....|.||:.|                    |.||... ||.||
  Fly   296 QASLKNVAQFK------DVVSIKTCTLPKEKL--------------------SKSGENT-TEPEL 333

  Fly   511 QAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTK 575
            |                .||.               |..:..|.|:|       .....||
  Fly   334 Q----------------NFNC---------------NCQKIKTQIKI-------SASNNVE---- 356

  Fly   576 SDVAIERERAGQWIGNGYQPTMDVLSLLD----------------------QQIKAPAVARLNSL 618
             |:.|        ..||......:..|:|                      .:..|.|:....:|
  Fly   357 -DLVI--------TCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATL 412

  Fly   619 GPNASTESEMASYLH--------RKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGS 675
            |.|.||.|:....|.        .:..|..|||:....|..  |..|.|     ..:||.|:||.
  Fly   413 GSNKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELD--RALITP-----SAKIGVGQFGD 470

  Fly   676 VHSG-WLLRKSGAGE----------------ESR---LEVAIK--MLSDEHSNKQEFLREASVMM 718
            |:.| :.|.|.|.|:                :||   ::||||  ..:|:....:.||.||.:|.
  Fly   471 VYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQ 535

  Fly   719 RLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQ 783
            :.:|..|:|||||.....:.:|.|||.||.:..|:..:...::....|| :..|::..:.||||:
  Fly   536 KFDHPHIIRLIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLK-YCYQLSTALSYLESK 599

  Fly   784 HFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHAS 848
            .|||||:||||:|:::....|::|||:||.:...| .|..|.....||:|.:|||.|...|:.||
  Fly   600 KFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQS-YYHSTPTVALPIKWMSPESINFRRFTTAS 663

  Fly   849 DVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPT 913
            |||.|||.|||:..||..|:..:.|.|.|..:::|||||.|..||..:|::|..||...|..||.
  Fly   664 DVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPN 728

  Fly   914 FVYLTE 919
            |..:.|
  Fly   729 FKRIKE 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	17/96 (18%)
		ANK	117..241	CDD:238125	29/158 (18%)
		ANK repeat	124..151	CDD:293786	6/34 (18%)
		ANK repeat	153..184	CDD:293786	9/47 (19%)
		Ank_2	158..247	CDD:289560	20/98 (20%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	7/33 (21%)
		Ank_4	224..274	CDD:290365	8/49 (16%)
		SH2_Cterm_shark_like	287..395	CDD:198211	21/124 (17%)
		TyrKc	662..921	CDD:197581	105/280 (38%)
		PTKc_Syk_like	666..926	CDD:270650	105/276 (38%)
Fak	NP_001137718.1	B41	24..267	CDD:214604	55/318 (17%)
		FERM_B-lobe	152..257	CDD:271216	25/144 (17%)
		FERM_C_FAK1	263..394	CDD:270011	38/237 (16%)
		PTKc_FAK	450..744	CDD:133187	109/294 (37%)
		Pkinase_Tyr	462..736	CDD:285015	105/275 (38%)
		Focal_AT	1249..1376	CDD:281606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840