DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and ITK

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens


Alignment Length:288 Identity:103/288 - (35%)
Similarity:156/288 - (54%) Gaps:30/288 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   636 CSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML 700
            |.|....|....:...|  :.|:|.:|...:|||.|:||.||.|:.|.|.        :||||.:
Human   339 CFGRQKAPVTAGLRYGK--WVIDPSELTFVQEIGSGQFGLVHLGYWLNKD--------KVAIKTI 393

  Fly   701 SDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHG-------- 757
            .:...::::|:.||.|||:|.|..:|:|.|:.        .|.||:..:.:: ::||        
Human   394 REGAMSEEDFIEEAEVMMKLSHPKLVQLYGVC--------LEQAPICLVFEF-MEHGCLSDYLRT 449

  Fly   758 -HEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY 821
             ..:.|...|......:..||.|||....:||||||||.|:......|:|||||:|.:.  ..:|
Human   450 QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQY 512

  Fly   822 QFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERL 886
            ..:.|.::|::|.:||.|:...:|..||||||||.:||:||.|..||...||.:.::.:.:|.||
Human   513 TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 577

  Fly   887 PQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .:|.|...::|.:|..||||||:|||.|
Human   578 YKPRLASTHVYQIMNHCWKERPEDRPAF 605

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 97/262 (37%)
PTKc_Syk_like 666..926 CDD:270650 96/258 (37%)
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841